By stimulating active absorption of calcium, and phosphorusCalcitriol plays a critical role in regulating mineral and bone.Metabolism in the adult. Without calcitriol intestinal absorption, is.Impaired secondary hyperparathyroidism, resorbs mineral from.Existing bone and new, bone cannot be fully mineralized (rickets or.Osteomalacia). These observations predict that vitamin D deficiency.Might be even more damaging during pregnancy and lactation.When the mother must deliver calcium to the fetus and neonate.However specific adaptations, invoked during pregnancy and lactation.Enable the mother to provide the necessary mineral without.Requiring calcitriol or vitamin D. So too the developing fetus does.Not require calcitriol for mineral homeostasis or skeletal development.It is after birth that neonates become dependent upon calcitriol.For intestinal calcium absorption and skeletal mineralization.The goal of this review is to provide a clearer understanding of.The known skeletal and non-skeletal roles of calcitriol in human.Metabolism during pregnancy lactation and fetal and neonatal,,,Development. Animal data are discussed because many aspects of.The role of calcitriol in pregnancy fetal and early neonatal development,,,May never be directly studied in humans. The available.Human and animal data appear largely in agreement but not, all.Animal data may be relevant to humans. In order to keep to the.Prescribed, citation limit the reader is referred to several.
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