AbstractThe mechanisms by which cyc

Abstract
The mechanisms by which cyclooxygenase inhibitors exert antitumor
effects are not completely defined but are postulated to involve antiangiogenic
effects and induction of apoptosis. In this study, we determined the
effects of the cox inhibitor, piroxicam, on tumor response, apoptotic index,
proliferative index, cyclooxygenase-2 expression, prostaglandin E2 concentration,
tumor microvessel density, and urine basic fibroblast growth
factor and vascular endothelial growth factor concentrations in pet dogs
with naturally occurring invasive transitional cell carcinoma of the urinary
bladder. Piroxicam caused reduction in tumor volume in 12 of 18
dogs, and this was strongly associated with induction of apoptosis (Fisher’s
exact test P < 0.015) and reduction in urine basic fibroblast growth
factor concentration.

ผลลัพธ์ (อังกฤษ) 2:

Abstract
The Mechanisms by which cyclooxygenase inhibitors Exert antitumor
effects are not completely defined but are postulated to involve antiangiogenic
effects and induction of apoptosis. In this Study, we determined the
effects of the Cox inhibitor, piroxicam, on tumor Response, apoptotic index,
proliferative index, cyclooxygenase-2 Expression, prostaglandin E2 concentration,
tumor Microvessel density, and urine Basic fibroblast growth
factor and vascular endothelial growth factor concentrations. PET in Dogs
Naturally occurring with invasive carcinoma of the Transitional Cell urinary
bladder. Piroxicam reduction in tumor volume caused in 12 of 18
Dogs, and this was strongly associated with induction of apoptosis (Fisher's
Exact Test P <0.015) and reduction in urine Basic fibroblast growth
factor concentration.

ผลลัพธ์ (อังกฤษ) 3:

Abstract
The mechanisms by which cyclooxygenase inhibitors exert antitumor
effects are not completely defined but are postulated. To involve antiangiogenic
effects and induction of apoptosis. In, this study we determined the
effects of the, COX inhibitor. Piroxicam on response, tumor, index apoptotic, index
proliferative, expression cyclooxygenase-2, E2, prostaglandin concentration
.Tumor microvessel density and urine, basic fibroblast growth
factor and vascular endothelial growth factor concentrations. In pet dogs
with naturally occurring invasive transitional cell carcinoma of the urinary
bladder. Piroxicam caused reduction. In tumor volume in 12 of 18
dogs and this, was strongly associated with induction of apoptosis (Fisher 's
exact test P < 0.015) and reduction in urine basic fibroblast growth
factor concentration.