Harmacokinetics:Absorption: 20-80% (oral). Absorption depends on the presence of bile and on normal pancreatic function; decrease with. Increasing dose.Distribution: Enters blood via the chylomicrons in the lymph; bound to β - lipoproteins. Widely distributed to all, tissues. Stored in adipose tissue. Enters breast milk but crosses the placenta poorly.Metabolism: Hepatic; converted to glucuronides of tocopheronic acid and its γ - lactone.Excretion: Excreted mainly via bile into faeces and some into urine.
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