Hyperbaric oxygen (HBO) treatment h

Hyperbaric oxygen (HBO) treatment has been used clinically to treat a variety of ailments, including
severe burns and carbon monoxide poisoning, and in research settings has produced promising results
when used to treat animal models of inflammatory pain. However, studies examining neuropathic pain
or nerve injury models have been limited to physiological assessments and not whether the pain
condition improves. The purpose of this study was to evaluate the effect of HBO on two common models
of neuropathic pain, L5 ligation and chronic constriction injury (CCI) of the sciatic nerve. Following
surgical manipulations, animals demonstrating mechanical hyperalgesia were randomly assigned to
either HBO treatment or control for 90 min treatment sessions, after which mechanical sensitivity was
assessed at 15 min and 6 h post. Daily HBO sessions, with assessments 15 min post-treatment, continued
for two weeks, followed by 5 days of assessment only. The results indicated that both models
demonstrated significant improvement in response to treatment over the course of the two-week period,
with CCI animals recovering more quickly and maintaining this recovery throughout the post-treatment
period. Hyperbaric oxygen treatment appears to be successful in relieving neuropathic pain for an
extended period of time, and future research should be aimed at investigating the precise mechanisms
underlying this positive effect.

ผลลัพธ์ (อังกฤษ) 3:

Hyperbaric oxygen (HBO) treatment has been used clinically to treat a variety of ailments, including
severe burns and carbon monoxide poisoning, and in research settings has produced promising results
when used to treat animal models of inflammatory pain. However, studies examining neuropathic pain
or nerve injury models have been limited to physiological assessments and not whether the pain
condition improves. The purpose of this study was to evaluate the effect of two common models on HBO
of neuropathic pain, and chronic constriction injury ligation L 5 (CCI) of the sciatic nerve. Following
surgical manipulations, animals demonstrating mechanical hyperalgesia
were randomly assigned to either treatment or control HBO treatment for 90 min sessions,after which
mechanical sensitivity was assessed at 15 MIN and 6 h POST. Daily HBO sessions, with assessments 15 min post-treatment,
continued for two weeks, followed by 5 days of assessment only. The results indicated that both models
demonstrated significant improvement in response to treatment over the course of the two-week period,
With CCI animals recovering more quickly and maintaining this recovery throughout the post-treatment period
. Hyperbaric oxygen treatment appears to be successful in relieving neuropathic pain
for an extended period of time, and future research should be aimed at investigating the precise mechanisms underlying
this positive effect.