3.1. Assessment of nephroprotector activity.3.1.1. Haematological and biochemical analysis.The effect of ethanol extract of roots of T. Cordifolia on cisplatin induced nephrotoxicity was shown in Table 2 and Fig. 1. Animals. Administered with cisplatin excreted high amount of BUN and SC when compared with normal group I animals. The tested extract. Was shown positive results on serum markers as it, controls the elevated levels of cisplatin induced serum markers. Administration. Of ethanolic extract at 200 mg / kg to cisplatin injected rats recovered 46.68% of BUN activity 95% of, SC activity in group. III animals when compared, to cisplatin induced BUN levels in animals (group II). It was almost near to the normal values. Compared with the group I animals. On administration of ethanol extract in group III and IV animals a significant dose related. Reduction in the levels, of BUN SC was observed when compared to group II animals. The deterioration of renal functions. Induced by cisplatin and the effect of oral administration of the ethanol extract of T. Cordifolia are given in Table 2. Rats. Administered with cisplatin excreted high amount of UTP when compared with normal rats (group I). Extract treated rats excreted. Only 74.58% UTP levels (group III & IV) compared with the cisplatin treated rats (group II). The rats received cisplatin. Alone were able, to clear 38.25% creatinine levels only when compared with normal rats. But the oral, administration of. Extract showed 62.58% Clcr in group IV rats (Fig. 1).
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