Recently, drug abuse has become a serious social problem world wide. In Japan, methamphetamine (MP) is the
most popular drug of abuse. In addition to MP, the use of 4,5-methylenedioxymethamphetamine (MDMA), called
ecstacy, is rapidly increasing, especially among young people. The development of simple and convenient analytical
methods for the analysis of these drugs of abuse is necessary for the prediction of and protection from human health
risks. Many useful methods have been developed for qualification and quantification of drugs of abuse. Among
these, gas chromatography with mass spectrometry (MS) and high-performance liquid chromatography with MS
(HPLC-MS or LC-MS) or fluorescence (HPLC-FL) detection are widely used. As highly sensitive methods, precolumn
or postcolumn derivatization methods are commonly utilized in HPLC. This review focuses on HPLC methods used
for the practical analysis of drugs of abuse, mainly for amphetamine derivatives and MDMAs in biologic samples
such as urine, blood, and hair.
Recently, drug abuse has become a serious social problem world wide. In Japan, methamphetamine (MP) is themost popular drug of abuse. In addition to MP, the use of 4,5-methylenedioxymethamphetamine (MDMA), calledecstacy, is rapidly increasing, especially among young people. The development of simple and convenient analyticalmethods for the analysis of these drugs of abuse is necessary for the prediction of and protection from human healthrisks. Many useful methods have been developed for qualification and quantification of drugs of abuse. Amongthese, gas chromatography with mass spectrometry (MS) and high-performance liquid chromatography with MS(HPLC-MS or LC-MS) or fluorescence (HPLC-FL) detection are widely used. As highly sensitive methods, precolumnor postcolumn derivatization methods are commonly utilized in HPLC. This review focuses on HPLC methods usedfor the practical analysis of drugs of abuse, mainly for amphetamine derivatives and MDMAs in biologic samplessuch as urine, blood, and hair.
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Recently, drug abuse has become a serious social problem world wide. In Japan, methamphetamine (MP) is the
Most popular of Drug abuse. In addition to MP, the use of 4,5-methylenedioxymethamphetamine (MDMA), Called
Ecstacy, is rapidly increasing, especially among Young people. Development of the Simple and Convenient analytical
methods for the Analysis of Drugs of abuse these is necessary for the prediction of Health and Human Protection from
risks. Many useful methods have been developed for qualification and quantification of drugs of abuse. Among
these, Gas chromatography with mass spectrometry (MS) and High-Performance Liquid chromatography with MS
(HPLC-MS or LC-MS) or fluorescence (HPLC-FL) are widely used Detection. As highly sensitive methods, precolumn derivatization
or methods are commonly utilized in Postcolumn derivatization HPLC. This review focuses on HPLC methods used
for the practical Analysis of Drugs of abuse, mainly for amphetamine derivatives and MDMAs in biologic samples
such as urine, Blood, and Hair.
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Recently drug abuse, has become a serious social problem world wide. In, Japan methamphetamine (MP) is the.Most popular drug of abuse. In addition, to MP the use of, 4 5-methylenedioxymethamphetamine (MDMA), called.Ecstacy is increasing, rapidly, among especially young people. The development of simple and convenient analytical.Methods for the analysis of these drugs of abuse is necessary for the prediction of and protection from human health.Risks. Many useful methods have been developed for qualification and quantification of drugs of abuse. Among.These gas chromatography, with mass spectrometry (MS) and high-performance liquid chromatography with MS.(HPLC-MS or LC-MS) or fluorescence (HPLC-FL) detection are widely used. As highly, sensitive methods precolumn.Or postcolumn derivatization methods are commonly utilized in HPLC. This review focuses on HPLC methods used.For the practical analysis of drugs of abuse mainly for, amphetamine derivatives and MDMAs in biologic samples.Such as, and blood urine, hair.
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