Of alcohol poisoning that caused the destruction of liver cells around the central vein area is expected to occur because the enzyme cytochrome P450 CYP2E1 when a large amount of ethanol. It has spurred the increase. Metabolism of alcohol through this system will yield more common. In particular, free radicals and hydrogen peroxide (hydrogen peroxide), while the area around the central vein were resistant to oxidation. And less oxygen, which is harmful to the cells increases. The destruction of liver cells, resulting in liver enzymes AST and ALT liver and a higher volume of blood.
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