PigmentsProdigiosin, a nondiffusibl

Pigments
Prodigiosin, a nondiffusible red pigment, is a secondary
metabolite formed by the enzymatic
condensation of 2-methyl-3-amylpyrrole (MAP)
and 4-methoxy-2,2$-bipyrrole-5-carboxyaldehyde
(MBC), leading to a tripyrrole derivative, 2-
methyl-3-amyl-6-methoxyprodigiosene (Williams
and Qadri, 1980). Little is known about the
biosynthetic pathways of MAP or MBC, except
that a proline molecule is incorporated intact
into one of the pyrrole groups of MBC (Williams
and Qadri, 1980). Pigment synthesis require air,
probably molecular oxygen. In the genus Serratia,
prodigiosin is only produced by strains of S.
marcescens, S. plymuthica, and S. rubidaea. In S.
marcescens, prodigiosin is produced by biogroups
A1 and A2/6 and never by biogroups A3,
A4, A5/8, or TCT (Grimont, P. A D., 1977). Nonpigmented
strains of biogroups A1 or A2/6 are
often blocked in the synthesis of either MAP or
MBC (Grimont, P. A. D., 1977; Williams and
Qadri, 1980). Strains in the nonpigmented biogroups
are likely to lack the condensing enzyme
(Ding and Williams, 1983). Some genes encoding
prodigiosin biosynthesis were cloned by Dauenhauer
et al. 1984 and expressed in Escherichia
coli. The clones obtained had acquired the ability
to condense MAP with MBC or to produce MAP
in addition to the condensing enzyme

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Pigments Prodigiosin, a nondiffusible red pigment, is a secondary metabolite formed by the enzymatic

condensation of 2-methyl- 3-amylpyrrole (MAP)
and 4-methoxy-2, 2 $ -bipyrrole - 5-carboxyaldehyde
(MBC), leading to a tripyrrole derivative, 2-methyl
- 3 - amyl - 6 - methoxyprodigiosene (Williams
and Qadri, 1980). Little is known about the biosynthetic pathways of
MAP or MBC, except
a molecule that proline is incorporated into one of the intact
pyrrole groups of MBC (Williams
and Qadri, 1980). Pigment synthesis require air,
probably molecular oxygen.The genus In Serratia,
prodigiosin is only produced by strains of S.
marcescens, S.plymuthica, and S.rubidaea. In S.
marcescens, prodigiosin is produced by biogroups
A A 1 and 2 /6 and never by A biogroups 3,
A 4, A 5/8,or TCT (Grimont, P.A D., 1977 ). Nonpigmented
strains of biogroups A A 1 or 2 /6
are often blocked in the synthesis of either MAP or
MBC (Grimont, P.A.D., 1977 ; and
Williams Qadri, 1980). In the nonpigmented Strains
biogroups are likely to lack the condensing enzyme
(Ding and Williams, 1983 ). Some genes encoding
prodigiosin biosynthesis were cloned by Dauenhauer
et al.1984 and expressed in Escherichia
coli. The clones obtained had acquired the ability to condense
MAP MBC with or to produce MAP
in addition to the condensing enzyme