ObjectivesThe existing research fin

Objectives

The existing research findings regarding the effects of lemongrass (Cymbopogon citratus) tea on renal function indices are conflicting and inconclusive. In the present study, we investigated the effects of infusions prepared from C citratus leaves on creatinine clearance rate (CCr) and estimated glomerular filtration rate (eGFR) in humans.

Design and Methods

One hundred five subjects (55 men and 50 women) aged 18 to 35 years were randomly assigned to groups set to orally receive infusions prepared from 2, 4, or 8 g of C citratus leaf powder once daily, for 30 days. Serum and urinary levels of urea, creatinine, pH, specific gravity, uric acid, electrolytes, diuretic indices, and eGFR were assessed at days 0, 10, and 30 after the initiation of treatment. Results obtained on days10 and 30 were compared with baseline values.

Results

CCr and eGFR decreased significantly at day 30 in both male and female subjects in all the groups and in females treated with infusion prepared from 8 g of C citratus leaf powder for 10 days. At day 10, CCr and eGFR were unchanged in those treated with infusions prepared from 2 or 4 g of the leaf powder, whereas diuretic indices (urine volume, urination frequency, diuretic action, and saliuretic indices) increased above the baseline levels. Serum and urinary creatinine levels significantly increased (P < .05) in both male and female subjects in all the groups. Serum urea significantly increased in the groups treated with infusions prepared from 4 or 8 g of the leaf powder (P < .05) for 30 days. Serum electrolytes remained unchanged, but their urinary levels increased.

Conclusions

We observed dose- and time-dependent adverse effects of C citratus on CCr and eGFR. At a high dose or with prolonged treatment with a low dose, eGFR decrease may be followed by a decline in the other renal function indices.

ผลลัพธ์ (อังกฤษ) 2:

Objectives The findings regarding the effects of existing Research lemongrass (Cymbopogon citratus) Tea on renal function indices are conflicting and Inconclusive. In the present Study, we investigated the effects of infusions prepared from C citratus leaves on creatinine clearance rate (CCr) and estimated glomerular Filtration rate (eGFR) in Humans. Design and Methods One Hundred Five subjects (55 Men and 50 Women) Aged 18. to 35 years were randomly assigned to groups set to orally receive infusions prepared from 2, 4, or 8 g of C citratus leaf powder once daily, for 30 days. Serum and urinary levels of urea, creatinine, pH, specific gravity, uric acid, electrolytes, diuretic indices, and eGFR were assessed at days 0, 10, and 30 after the initiation of treatment. Results obtained were compared with 30 on Days10 and baseline values. Results CCr and eGFR Decreased significantly at Day 30 in both male and female subjects in all the groups and in females treated with infusion prepared from 8 G of C citratus Leaf Powder for 10 days. At day 10, CCr and eGFR were unchanged in those treated with infusions prepared from 2 or 4 g of the leaf powder, whereas diuretic indices (urine volume, urination frequency, diuretic action, and saliuretic indices) increased above the baseline levels. Serum and urinary creatinine levels significantly increased (P <.05) in both male and female subjects in all the groups. Serum urea significantly increased in the groups treated with infusions prepared from 4 or 8 g of the leaf powder (P <.05) for 30 days. Serum electrolytes remained unchanged, but their urinary Increased levels. Conclusions We observed time-dependent adverse effects of Dose and C citratus on CCr and eGFR. At a high dose or with prolonged treatment with a low dose, eGFR decrease may be followed by a decline in the other renal function indices.

ผลลัพธ์ (อังกฤษ) 3:

Objectives

The existing research findings regarding the effects of lemongrass (Cymbopogon citratus) tea on renal function. Indices are conflicting and inconclusive. In the, present study we investigated the effects of infusions prepared from C. Citratus leaves on creatinine clearance rate (CCr) and estimated glomerular filtration rate (eGFR) in humans.

Design and. Methods

.One hundred five subjects (55 men and 50 women) aged 18 to 35 years were randomly assigned to groups set to orally receive. Infusions prepared, from 2 4 or 8, g of C citratus leaf powder once daily for 30, days. Serum and urinary levels, of urea. Creatinine pH specific gravity,,,,, uric acid electrolytes diuretic indices and eGFR, were assessed at days 0 10,,And 30 after the initiation of treatment. Results obtained on days10 and 30 were compared with baseline values.



, Results CCr And eGFR decreased significantly at day 30 in both male and female subjects in all the groups and in females treated with. Infusion prepared from 8 g of C citratus leaf powder for 10 days At, day 10.CCr and eGFR were unchanged in those treated with infusions prepared from 2 or 4 g of the leaf powder whereas diuretic,, Indices (urine, frequency volume urination, action and diuretic, saliuretic indices) increased above the baseline, levels. Serum and urinary creatinine levels significantly increased (P <. 05) in both male and female subjects in all the groups.Serum urea significantly increased in the groups treated with infusions prepared from 4 or 8 g of the leaf powder (P <. . 05) for 30 days. Serum electrolytes remained unchanged but their, urinary levels increased.



We Conclusions observed dose -. And time-dependent adverse effects of C citratus on CCr and eGFR. At a high dose or with prolonged treatment with a low. Dose.EGFR decrease may be followed by a decline in the other renal function indices.