Further reaction with the substance. When you understand the message, and then the reader will need to have a reaction in response to the substance. The reader will read a story or message that will be accepted or rejected.
The substances react when that material. The reader must have reacted to the substance. Readers are evaluating or have the story read to accept or decline.
the substance. Readers will need to have a reaction to the substance to it. Readers will evaluate the message or story read whether to accept or refuse.