Fig. 3 shows the water vapor sorption isotherms of Met API and Met granulates produced, with VA64 PVP and HPC. Met, API. Is able to absorb only a very small amount of moisture (0.011%: at, 50% RH 0.097%: at 90% RH). Solubility of Met API is. Over 100 mg / ml in water [4]. When the added water amount was 1.5% during the MAG process the Met, API may be crystalline. (over 99%) during the MAG process based on the calculation of the added water amount in MAG and Met API solubility. On the. Other hand Met granulates, produced with the various binders showed much higher moisture absorbency than Met API, Therefore,. Binders may have a significant impact on the moisture uptake of Met granulates.
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