As part of the Canadian Healthy Inf

As part of the Canadian Healthy Infant Longitudinal Development (CHILD) study, Finlay and colleagues collected stool and urine samples from more than 300 babies at 3 months and 1 year old, as well as information on their health at 1, 3, and 5 years. Then, they used high-throughput genetic sequencing to detect levels of gut microbes in each stool sample. Babies that had low or undetectable levels of four bacteria—Lachnospira, Veillonella, Faecalibacterium, and Rothia—at 3 months old all went on to show early signs of asthma—wheezing and skin allergies—at a year old. The babies who didn’t develop these symptoms invariably had high levels of the four microbes in their 3-month stool samples.

The association held “quite consistently” and was “very” statistically significant, Finlay says. In addition to differences in stool bacteria, the team found differences in the urine of the babies who went on to develop asthma. Certain bacterial byproducts were at lower or higher levels, hinting that these chemicals—produced in the gut but distributed throughout the body—could act on the immune system to make it more susceptible to the disease.

Next, Finlay’s group used stool samples from the asthma-prone 3-month-olds to colonize the guts of mice that had been raised in a bacteria-free environment. The animals went on to develop inflamed lungs indicative of asthma. But if the researchers added a mixture of the four missing microbes to the mice’s digestive tracts along with the feces, the mice no longer had a heightened risk of developing asthma, the scientists report online today in Science Translational Medicine.

The discovery has one immediate application: identifying children with a high risk of asthma in their first 100 days of life, says pediatrician Stuart Turvey of UBC Vancouver, a co-author on the paper. “Those children could be followed or treated more quickly if they end up with asthma,” he adds. But it also suggests that providing this group with the unique mixture of four bacteria—a combination not found in current commercial probiotics—could prevent the onset of asthma.

But developing therapeutics will be harder than just mixing the microbes together into pill form, Wills-Karp says, because babies already have guts that are teeming with other bacteria. These “first colonists” may prevent new strains from easily taking over. And another study has suggested different bacteria as protective. “It’s not clear right now that there are ways to induce the growth of these particular bacteria in kids,” she says. “But it certainly starts to open the door toward that possibility.”

Finlay and Turvey’s team is continuing to follow the health of the first group of children, studying which go on to develop true asthma—so far, more than a third of those who developed the early signs of the disease have the full-blown version. In addition—since the microbiomes of people in various cultures are known to differ—they’re repeating the experiment in a larger, more diverse set of children, including some from Ecuador, to see whether the four strains of bacteria are universally important.

ผลลัพธ์ (อังกฤษ) 2:

As part of the Canadian Healthy Infant Longitudinal Development (CHILD) study, Finlay and colleagues collected stool and urine samples from more than 300 babies at 3 months and 1 year old, as well as information on their health at 1, 3, and 5 years. . Then, they used high-throughput genetic sequencing to detect levels of gut microbes in each stool sample. Babies that had low or undetectable levels of four bacteria-Lachnospira, Veillonella, Faecalibacterium, and Rothia-at 3 months old all went on to show early signs of asthma-wheezing and skin allergies-at a year old. Babies Who did not develop the symptoms Invariably these had High levels of the microbes in their 3-month Four stool samples. The association held "quite consistently" and was "very" statistically significant, Finlay says. In addition to differences in stool bacteria, the team found differences in the urine of the babies who went on to develop asthma. Certain bacterial byproducts were at Lower or higher levels, hinting that these chemicals-produced in the Gut but Distributed throughout the Body-could Act on the immune System to Make it more susceptible to the disease. Next, Finlay's Group used stool samples from the asthma. -prone 3-month-olds to colonize the guts of mice that had been raised in a bacteria-free environment. The animals went on to develop inflamed lungs indicative of asthma. But if the researchers added a mixture of the Four Missing microbes to the mice's Digestive tracts along with the Feces, the mice no Longer had a heightened risk of developing asthma, the scientists Report Online today in Science Translational Medicine. The Discovery has one immediate Application. : identifying children with a high risk of asthma in their first 100 days of life, says pediatrician Stuart Turvey of UBC Vancouver, a co-author on the paper. "Those children could be followed or treated more quickly if they end up with asthma," he adds. But also suggests that providing this Group Four with the Unique mixture of bacteria-a combination not Found in current Commercial Prevent the onset of asthma probiotics-could. But developing Therapeutics Will be harder than just mixing the microbes Together Into Pill form, Wills-. Karp says, because babies already have guts that are teeming with other bacteria. These "first colonists" may prevent new strains from easily taking over. And another study has suggested different bacteria as protective. "It's not clear right now that there are ways to induce the growth of these particular bacteria in kids," she says. "But certainly starts to open the door toward that possibility." Finlay and Turvey's Team is Continuing to follow the Health of the First Group of children, studying which Go on to develop true asthma-so Far, more than a third of those Who. developed the early signs of the disease have the full-blown version. In addition-since the microbiomes of people in various cultures are known to differ-they're repeating the experiment in a larger, more diverse set of children, including some from Ecuador, to see whether the four strains of bacteria are universally important.

ผลลัพธ์ (อังกฤษ) 3:

As part of the Canadian Healthy Infant Longitudinal Development (CHILD), study Finlay and colleagues collected stool and. Urine samples from more than 300 babies at 3 months and 1, year old as well as information on their health, at 1 3 and 5, years.? Then they used, high-throughput genetic sequencing to detect levels of gut microbes in each stool sample.Babies that had low or undetectable levels of four bacteria -,,, Lachnospira Veillonella Faecalibacterium and Rothia - at 3 months. Old all went on to show early signs of asthma - wheezing and skin allergies - at a year old. The babies who didn t develop these. ' Symptoms invariably had high levels of the four microbes in their 3-month stool samples.

.The Association held "quite consistently." and was "very", statistically significant Finlay says. In addition to differences. In stool bacteria the team, found differences in the urine of the babies who went on to develop asthma. Certain bacterial. Byproducts were at lower or, higher levelsHinting that these chemicals - produced in the gut but distributed throughout the body - could act on the immune system to. Make it more susceptible to the disease.

Next Finlay ', s group used stool samples from the asthma-prone 3-month-olds to. Colonize the guts of mice that had been raised in a bacteria-free environment. The animals went on to develop inflamed lungs. Indicative of asthma.But if the researchers added a mixture of the four missing microbes to the mice 's digestive tracts along with, the feces. The mice no longer had a heightened risk of developing asthma the scientists, report online today in Science Translational. Medicine.

The discovery has one immediate application: identifying children with a high risk of asthma in their first 100 days. Of, lifeSays pediatrician Stuart Turvey of, UBC Vancouver a co-author on the paper. "Those children could be followed or treated. More quickly if they end up with asthma, "he adds. But it also suggests that providing this group with the unique mixture. Of four bacteria - a combination not found in current commercial probiotics - could prevent the onset of asthma.

.But developing therapeutics will be harder than just mixing the microbes together into pill form Wills-Karp says because,,, Babies already have guts that are teeming with other bacteria. These "first colonists." may prevent new strains from easily. Taking over. And another study has suggested different bacteria as protective."It 's not clear right now that there are ways to induce the growth of these particular bacteria in kids," she says. "But. It certainly starts to open the door toward that possibility. "

Finlay and Turvey 's team is continuing to follow the health. Of the first group, of children studying which go on to develop true asthma - far so,More than a third of those who developed the early signs of the disease have the full-blown version. In addition - since. The microbiomes of people in various cultures are known to differ - they 're repeating the experiment in a larger more diverse,, Set of children including some, from Ecuador to see, whether the four strains of bacteria are universally important.