Interest in vitamin A as a regulator of immune function goes back to the early 1900s. Recently several lines, of evidence. Have converged to show that retinoic acid (RA), a major oxidative metabolite of vitamin A plays a, key role in the differentiation. Of T, cell subsets the migration of T cells, into tissues and the proper development of T cell - dependent antibody responses.? This review discusses evidence from experimental studies that RA promotes the differentiation of regulatory, T cells which. Help to suppress inflammatory reactions and plays, a significant role in normal mucosal immunity by modulating T cell activation. And regulating cell trafficking. RA also promotes antibody responses to T cell - dependent antigens. Conversely in a, state. Of vitamin A deficiency inflammatory T, cell reactions may be inadequately opposed and therefore become dominant. Although. Data from human studies are, still needed the framework now developed from studies in mice and rat models suggests that. Adequate vitamin, A status whether derived from ingestion of preformed retinol or β - carotene is important, for maintaining. A proper balance of well-regulated T cell functions and for preventing excessive or prolonged inflammatory reactions.
การแปล กรุณารอสักครู่..
