Introduction: Abruptio placentae, defined as premature separation of a normally implanted placenta, is
a life threatening pregnancy complication with unknown pathophysiology. A history of abruptio placentae
is the major risk factor for this pregnancy complication in humans. We describe the first case of
recurrent abruptio placentae in a Macaca fascicularis.
Material and methods: A pregnant M. fascicularis at term gestation was presented with weakness and
hypothermia. Cesarean section revealed retroplacental hemorrhage with partial placental separation
from the uterus.
Results: The weight of the female fetus was within the lower birth weight range for these species. The
maternal side of placenta contained necrotic tissue, occupying approximately 60% of the maternal surface.
The placental implantation bed demonstrated neutrophil infiltration. Perivascular collections of
lymphocytes were noticed in the uterine smooth muscle.
Conclusion: This case report underlines the importance of neutrophil infiltration and uterine venous
drainage in the cascade of events leading to abruptio placentae.