อายุเราห่างกัน 15 ปี

อายุเราห่างกัน 15 ปี

ผลลัพธ์ (อังกฤษ) 1:

I was away for 15 years

ผลลัพธ์ (อังกฤษ) 2:

The aim of
this study was to examine whether 6-shogaol inhibits AD-like skin lesions and their
underlying mechanism in vivo and in vitro. An AD-like response was induced by tumor
necrosis factor-α (TNF-α) + IFN-γ in human keratinocytes or by 2,4-dinitrochlorobenzene
(DNCB) in mice. In vivo, 6-shogaol inhibited the development of DNCB-induced AD-like
skin lesions and scratching behavior, and showed significant reduction in Th2/1-mediated
inflammatory cytokines, IgE, TNF-α, IFN-γ, thymus and activation-regulated chemokine, IL-
1, 4, 12, and 13, cyclooxygenase-2, and nitric oxide synthase levels. In vitro, 6-shogaol
inhibited reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs)
signaling, and increased the levels of total glutathione, heme oxygenase-1, and quinone 1 via
nuclear factor erythroid 2 related factor 2 (Nrf2) activation. 6-shogaol can alleviate AD-like
skin lesions by inhibiting immune mediators via regulating the ROS/MAPKs/Nrf2 signaling
pathway, and may be an effective alternative therapy for AD.

ผลลัพธ์ (อังกฤษ) 3:

We are fifteen years old.