A recent investigation by Enan et al. (1998) using the.American cockroach points to the octopaminergic nervous.System as the site-of-action in insects. The binding.Of 3H-octopamine in a cockroach nerve cord protein.Preparation was signi "cantly a! Ected in the presence of.A number of essential oil constituents. The lack of octopamine.Receptors in vertebrates likely accounts for the.Profound mammalian selectivity of essential oils as insecticides.(i.e. They are toxic to insects but not to mammals),And thus the octopaminergic system of insects represents.A biorational target for insect control. Investigation of.The formamidine insecticides revealed interesting and potentially.Important sublethal behavioral and physiological.E! Ects presumably mediated, by the octopaminergic.Nervous system (Matsumura, and Beeman 1982). Sublethal.E! Ects observed with some of the essential oil.Compounds (viz, feeding deterrence repellency), may be.Consistant with this mode-of-action.
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