The conjunctiva contains non-kerati

The conjunctiva contains non-keratinising, squamous epithelium and a thin, richly vascularised substantia propria. The conjunctiva also has accessory lacrimal glands and goblet cells.Allergic conjunctivitis is caused by a type I immune response to an allergen. The allergen binds to a mast cell and cross-linking to IgE occurs, leading to mast cell degranulation and initiation of an inflammatory cascade. This results in release of histamine from mast cells, as well as other mediators, including tryptase, chymase, heparin, chondroitin sulphate, prostaglandins, thromboxane, and leukotrienes. Histamine and bradykinin immediately stimulate nociceptors, resulting in itching, increased vascular permeability, vasodilation, redness, and conjunctival injection.Infective conjunctivitis occurs as a result of reduced host defences and external contamination. Infectious pathogens can invade from adjacent sites or by a blood-borne pathway and replicate within the conjunctival mucosal cells. Both bacterial and viral infections initiate a leukocyte or lymphocytic inflammatory cascade leading to the attraction of red and white blood cells to the area. These white blood cells reach the conjunctival surface and accumulate there by easily moving through the dilated and highly permeable capillaries.

The conjunctiva, contains non-keratinising squamous epithelium and a thin richly vascularised, substantia propria. The. Conjunctiva also has accessory lacrimal glands and goblet cells.Allergic conjunctivitis is caused by a type I immune response to an allergen. The allergen binds to a mast cell and cross-linking. To IgE occurs leading to, mast cell degranulation and initiation of an inflammatory cascade. This results in release of. Histamine from mast cells as well, as other mediators including tryptase chymase,,,,,, heparin chondroitin sulphate prostaglandins. Thromboxane and, leukotrienes. Histamine and bradykinin immediately stimulate nociceptors resulting in itching increased,,, ,,, vascular permeability vasodilation redness and conjunctival injection.Infective conjunctivitis occurs as a result of reduced host defences and external contamination. Infectious pathogens can. Invade from adjacent sites or by a blood-borne pathway and replicate within the conjunctival mucosal cells. Both bacterial. And viral infections initiate a leukocyte or lymphocytic inflammatory cascade leading to the attraction of red and white. Blood cells to the area. These white blood cells reach the conjunctival surface and accumulate there by easily moving through. The dilated and highly permeable capillaries.