When you try to remove nicotine to rats and mice experiments that took nerve cells affected, the POMC mice have reduced POMC is body weight. While the weight of mice that do not have the POMC, unchanged.
The trial took nicotine to mice with normal POMC neurons and mice to cut out the results showed that the mice also POMC is weight reduction. While the body weight of the mice without POMC then remain the same.
When the trial took nicotine to rats and normal rats took the neurons POMC out, the results showed that rats have POMC are overweight. As the body weight of rats with no POMC and still the same.