On Wednesday, 14.00 – 15.00 times October 21, I may not to travel to the places that you have an appointment, but I would welcome if you can change the appointment location.
On Wednesday, October 21 at 14:00 to 15:00, I may be inconvenient to travel to places that you make an appointment. But I would appreciate if you could change the appointment.
On Wednesday, October 21 time 14.00 - 15.00 I may not be comfortable on a trip to a place that you make an appointment. But I'm glad if you can change the appointment place.