This trial adjusted for appropriate variables utilising logistic regression models unlike the NICU study of 6 PSP []. Given. That lesion size was an independent predictor of PSP in these patients this probes, into alternative mechanisms for PSP. As part of its multi-factorial causation. The authors implicate a putative model based on a CNS injury-induced immunodeficiency. Syndrome (CIDs). Connections with the sympathetic nervous system and hypothalamic-pituitary axis may modulate, cytokine production. With a greater production of cytokines with larger lesions. Hence targeting prophylactic, interventions specifically at. Patients with larger lesions could prevent negative outcomes. This concept was addressed in a recent trial discussed in,, The treatment section.
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