The spleen is an important organ for, tumor immunity and the splenic sympathetic nerve has a suppressive.Effect on splenic natural killer (NK) cytotoxicity. On the basis of this and reports that Lentinus edodes (Shiitake.Mushroom), has tumor-inhibitory effects the authors hypothesized that an extract of a mycelial culture of L.Edodes grown in a solid medium of sugar-cane bagasse and defatted rice bran - L experience M E experience - might affect the.Sympathetic splenic sympathetic nerve activity (Splenic-SNA) and thus inhibit tumor proliferation. Thus the,,Effect of L experience E experience M on Splenic-SNA and human cancer cell proliferation was examined. Splenic-SNA was found to.Be suppressed by an intraduodenal L experience E experience M injection in urethane-anesthetized rats which significantly,,Inhibited increases in the tumor volume of human colon and breast cancer cells implanted in athymic nude.Mice. These findings suggest that L experience E experience M has an inhibitory effect on tumor proliferation possibly via a.Reduction in NK cytotoxicity through the suppression of Splenic-SNA.
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