Biopharmaceutical proteins are almo

Biopharmaceutical proteins are almost universally manufactured
using animal cells or microbes cultivated in fermenters, and an entire industry
has evolved based on the standardization, optimization and regulation
of these platforms (Twyman et al., 2005). More recently,
biopharmaceutical products have been manufactured in plants, with
several candidates now in late-stage clinical development and one already
approved for human use (Fischer et al., 2013; Paul et al., 2013).
Plants offer numerous advantages during the upstream production
phase including the low cost of infrastructure and production, the
built-in safety features reflecting the inability of plants to support the
replication of human pathogens, and the unparalleled scalability of agricultural
production (Sabalza et al., 2014). Another key feature of plants
is the diversity of upstreamproduction systems, reflecting the use of different
plant species, tissues/cells, cultivation formats and expression
strategies, all of which can affect product yields and post-translational
modifications such as glycosylation (Arcalis et al., 2013; Khan et al.,
2012; Makhzoum et al., 2014).

ผลลัพธ์ (แอฟริกา) 1:

Biofarmaseutiese Proteïene is byna universeel Vervaardig
met behulp Animal selle of mikrobes gekweek in ferme, en 'n hele bedryf
het ontwikkel wat gebaseer is op die standaardisering, Optimization en Regulasie
van hierdie platforms (Twyman et al., 2005 die). Meer onlangs,
het biofarmaseutiese Produkte vervaardig in plante, met
verskeie Kandidate wat nou in 'n laat stadium kliniese Ontwikkeling en een wat reeds
goedgekeur is vir menslike gebruik (Fischer et al, 2013;.. Paul et al, die 2013th).
Plante bied talle voordele gedurende die. Produksie stroomop
Fase insluitende die lae koste van infrastruktuur en die produksie, die
ingeboude veiligheidseienskappe Besinning die onvermoë van Plante die ondersteuning
Replisering van Human patogene, en die ongekende scalability van Landbou
produksie (Sabalza et al., 2014 die). Belangrike kenmerk van 'n ander Plante
is die diversiteit van Upstreamproduction Systems, die gebruik van verskillende Besinning
plantspesies, weefsel / selle, verbouing formate en Expression
Strategies, wat almal raak produk opbrengste en Post-translasionele Can
modifikasies soos glycosylatie (arcalis et al. , die 2013th;. Khan et al,
2012;. Makhzoum et al, 2014).