Skeletal fluorosisOne solidly estab

Skeletal fluorosis

One solidly established concept in environmental health is that the effects of toxic agents fall on a continuum of biological change, ranging from undetectable effects at the lowest levels of exposure to severe health damage at very high doses. As exposure to an agent increases, the first detectable effect may be a subtle biochemical change, such as a decrease in the activity of an enzyme. At somewhat higher doses, measurable changes in some physiological functions may occur, but these often are not linked to clear symptoms or adverse effects, and may not be harmful. But as dosage increases, adverse effects begin to appear-at first mild ones, then moderate ones, and finally severe ones.

Most environmental health experts believe that the subtlest detectable effects-those with no outward symptoms, which are not clearly harmful-should be considered "precursors" of more serious effects. By this logic, people who show such subtle changes should be considered at risk for more serious effects if exposure continues.

Skeletal fluorosis, a complicated illness caused by the accumulation of too much fluoride in the bones, has a number of stages. The first two stages are preclinical-that is, the patient feels no symptoms but changes have taken place in the body. In the first preclinical stage, biochemical abnormalities occur in the blood and in bone composition; in the second, histological changes can be observed in the bone in biopsies. Some experts call these changes harmful because they are precursors of more serious conditions. Others say they are harmless.

In the early clinical stage of skeletal fluorosis, symptoms include pains in the bones and joints; sensations of burning, pricking, and tingling in the limbs; muscle weakness; chronic fatigue; and gastrointestinal disorders and reduced appetite. During this phase, changes in the pelvis and spinal column can be detected on x-rays. The bone has both a more prominent and more blurred structure.

In the second clinical stage, pains in the bones become constant and some of the ligaments begin to calcify. Osteoporosis may occur in the long bones, and early symptoms of osteosclerosis (a condition in which the bones become more dense and have abnormal crystalline structure) are present. Bony spurs may also appear on the limb bones, especially around the knee, the elbow, and on the surface of tibia and ulna.

In advanced skeletal fluorosis, called crippling skeletal fluorosis, the extremities become weak and moving the joints is difficult. The vertebrae partially fuse together, crippling the patient.

Most experts in skeletal fluorosis agree that ingestion of 20 mg of fluoride a day for 20 years or more can cause crippling skeletal fluorosis. Doses as low as 2 to 5 mg per day can cause the preclinical and earlier clinical stages.

The situation is complicated because the risk of skeletal fluorosis depends on more than the level of fluoride in the water. It also depends on nutritional status, intake of vitamin D and protein, absolute amount of calcium and ratio of calcium to magnesium in drinking water, and other factors.

In parts of India, China, Africa, Japan, and the Middle Fast, large numbers of people have skeletal fluorosis from drinking naturally fluoridated water. In India about a million people have this disease. Most of the victims live in areas where the water fluoride level is 2 ppm or above, but some cases are found in communities with natural fluoride levels below 1 ppm.

In the U.S., more than a dozen cases of skeletal fluorosis have been reported. Some have occurred at high fluoride levels, others at levels lower than 4 ppm when aggravating conditions were present, such as diabetes or impaired kidney function.

In setting the recommended maximum contaminant level for fluoride in drinking water in 1986, EPA considered only crippling skeletal fluorosis as a health effect and established little or no margin of safety, even for this disease. (A margin of safety is a difference between the maximum contaminant level and the level at which health effects first occur in the most susceptible individuals.) According to a Department of Agriculture survey, about 3% of the U.S. population drinks 4 L or more or water per day. Therefore, about 3 % of the people who live in areas where the water contains the natural fluoride level of 4 ppm allowed by EPA -- such as certain communities in Texas or South Carolina -- are ingesting at least 16 mg of fluoride a day, not including the fluoride they derive from other sources, such as toothpaste, food, or air.

Also, because a more or less constant percent of intake is accumulated in bone, persons who consume 8 mg a day for 50 years accumulate about the same amount of fluoride in their bones as those who consume 20 mg a day for 20 years. Therefore, for people who drink 2 L or more per day of water with 4 ppm fluoride throughout their lives, there appears to be no margin of safety even for crippling fluorosis. In its regulations for most other drinking water contaminants, EPA has included safety factors of 10 to 100 and has calculated intakes in terms of a lifetime—that is, 70 years instead of 20.

Joseph A. Cotruvo, director of the criteria and standards division of EPA’s Office of Drinking Water, says the fact that so few people in the U.S. have actually developed crippling skeletal fluorosis indicates that fluoride levels found in U.S. water are safe and that there is therefore an observed margin of safety. But critics of EPA’s standard speculate that there probably have been many more cases of fluorosis-even crippling fluorosis-than the few reported in the literature because most doctors in the U.S. have not studied the disease and do not know how to diagnose it.

Those who ingest much less than 20 mg of fluoride per day may still be at risk of developing less severe stages of skeletal fluorosis, such as preclinical forms or the subcrippling clinical stages. In its final report, the Surgeon General’s panel said that radiologic changes have been found in bone when fluoride exposure has been about 5 mg per day. Nearly all of those drinking water containing 4 ppm of fluoride and about 3% of the more than 124 million people whose water contains only 1 ppm would have intakes as high as this. It is not known, however, what fraction of those with low-level radiologic changes would suffer joint pains or other clinically obvious adverse health effects. In his landmark study of skeletal fluorosis in cryolite workers in the 1930s, the Danish scientist Kaj Roholm found that some of those with stage I of clinical skeletal fluorosis suffered joint pains and stiffness.

Although skeletal fluorosis has been studied intensely in other countries for more than 40 years, virtually no research has been done in the U.S. to determine how many people are afflicted with the earlier stages of the disease, particularly the preclinical stages. Because some of the clinical symptoms mimic arthritis, the first two clinical phases of skeletal fluorosis could be easily misdiagnosed. Skeletal fluorosis is not even discussed in most medical texts under the effects of fluoride; indeed, a number of texts say the condition is almost nonexistent in the U.S. Even if a doctor is aware of the disease, the early stages are difficult to diagnose.

The possibility that fluoride might cause skeletal abnormalities in children’s bones is of particular concern. In its April 1983 draft report, the Surgeon General’s committee wrote that moderate and severe dental fluorosis in children may be accompanied by skeletal changes. Although this statement was omitted from the final report in September 1983, the committee did urge more research into the skeletal effects of fluoride, particularly in children. It wrote: "The effects of various levels of fluoride intake on rapidly developing bone in young children are not well understood. Also, the modifying effects of total intake, length of exposure, other nutritional factors, and debilitating illness are not well understood." Since the committee’s report was written, PHS and EPA have undertaken no research in this area.

PHS has conducted several studies that it claims show that fluoride levels found in U.S. water supplies have had no clearly adverse effects on bones. But the majority of these studies either included a study population too small to detect rare effects or excluded people who would be most likely to suffer from skeletal fluorosis, such as those with kidney disease.

EPA’s approach to subtle, preclinical effects of fluoride on the skeleton differs from its usual approach to other environmental agents. For instance, when EPA assessed the health hazards of lead, it made an extraordinary effort to connect the observable effects of low-level exposure (inhibition of certain blood enzymes) with the known adverse effects of slightly higher exposure (decreased synthesis of hemoglobin, anemia, and possible neurotoxic effects). When it set its standard for lead in air, EPA argued that to prevent more serious effects, it needed to limit the more subtle biochemical changes that lead was provoking in millions of children.

By contrast, EPA’s assessment of fluoride in water took an almost opposite tack. By defining the most severe known hazard, crippling skeletal fluorosis, as the only effect it was concerned with preventing, EPA dismissed all degrees of fluoride-induced changes in bones less drastic than crippling fluorosis as not being health concerns.

Because fluoride causes denser bones (osteosclerosis), a number of researchers have compared fluoridated and nonfluoridated areas to see if the incidence and severity of osteoporosis is lower in fluoridated areas. A small number of studies in the past 25 years have reported a lower incidence of hip fractures in areas with fluoridated water, compared with nearby areas with low-fluoride water. For example. a recent report, comparing two towns in Finland, p

ผลลัพธ์ (อังกฤษ) 2:

Skeletal fluorosis One solidly Established Concept in Environmental Health effects is that The Fall of Toxic Agents on a Continuum of Biological Change, ranging from undetectable levels Lowest effects at The Health of Exposure to severe damage at very High doses. As exposure to an agent increases, the first detectable effect may be a subtle biochemical change, such as a decrease in the activity of an enzyme. At somewhat higher doses, measurable changes in some physiological functions may occur, but these often are not linked to clear symptoms or adverse effects, and may not be harmful. But As dosage Increases, adverse effects Begin to appear-at First Mild Ones, then moderate Ones, and finally severe Ones. Most Environmental Health Experts Believe that The subtlest detectable effects-those with no Outward symptoms, which are Not clearly harmful-should be. considered "precursors" of more serious effects. By this Logic, People Who show should be considered at risk Such subtle Changes for more Exposure Continues IF Serious effects. Skeletal fluorosis, a complicated illness caused by accumulation of The Too much fluoride in The bones, has a number of Stages. The first two stages are preclinical-that is, the patient feels no symptoms but changes have taken place in the body. In the first preclinical stage, biochemical abnormalities occur in the blood and in bone composition; in the second, histological changes can be observed in the bone in biopsies. Some experts call these changes harmful because they are precursors of more serious conditions. Say they are harmless others. In The Early Clinical Stage of Skeletal fluorosis, The symptoms include pains in bones and Joints; sensations of burning, pricking, and tingling in the limbs; muscle weakness; chronic fatigue; and gastrointestinal disorders and reduced appetite. During this phase, changes in the pelvis and spinal column can be detected on x-rays. Both The Bone has a more and more blurred Prominent structure. In The Second Clinical Stage, The pains in bones and some of The Constant Become ligaments Begin to calcify. Osteoporosis may occur in the long bones, and early symptoms of osteosclerosis (a condition in which the bones become more dense and have abnormal crystalline structure) are present. Bony spurs May also appear on The Limb bones, especially Around The knee, The elbow, and on The surface of Tibia and Ulna. In advanced Skeletal fluorosis, Called crippling Skeletal fluorosis, The Moving The Extremities and Joints is weak Become Difficult. The vertebrae partially fuse Together, crippling The Patient. Most Experts Agree in Skeletal fluorosis that fluoride ingestion of 20 mg of a Day for 20 years or more crippling Can Cause Skeletal fluorosis. As Low As 2 to 5 mg doses Per Day Can Cause The preclinical and Clinical Earlier Stages. The situation is complicated Because of Skeletal fluorosis The risk depends on more than The Level of fluoride in The Water. It also depends on Nutritional Status, Intake of Vitamin D and protein, Absolute amount of calcium and ratio of calcium to Magnesium in Drinking Water, and Other factors. In Parts of India, China, Africa, Japan, and The Middle Fast, Large numbers. of people have skeletal fluorosis from drinking naturally fluoridated water. In India about a million people have this disease. Most of The victims Live in areas Where The Water Level is 2 PPM fluoride or above, but some are Cases Found in Communities with natural fluoride levels Below 1 PPM. In The US, more than a dozen of Skeletal fluorosis Have been Reported Cases. Some Have occurred at High fluoride levels, others at levels Lower than 4 PPM When aggravating conditions were Present, Such As Diabetes or impaired Kidney function. In Setting The Recommended Maximum Contaminant Level for fluoride in Drinking Water in one thousand nine hundred eighty-six, EPA considered only crippling Skeletal fluorosis. as a health effect and established little or no margin of safety, even for this disease. (A margin of safety is a difference between the maximum contaminant level and the level at which health effects first occur in the most susceptible individuals.) According to a Department of Agriculture survey, about 3% of the US population drinks 4 L or more or. water per day. Therefore, about 3% of the people who live in areas where the water contains the natural fluoride level of 4 ppm allowed by EPA - such as certain communities in Texas or South Carolina - are ingesting at least 16 mg of fluoride a day,. Not including The fluoride they derive from Other Sources, Such As toothpaste, Food, or Air. Also, Because a more or less Constant Percent of Intake is accumulated in Bone, Persons Who Consume 8 mg a Day for 50 years accumulate About The Same amount. of fluoride in their bones as those who consume 20 mg a day for 20 years. Therefore, for people who drink 2 L or more per day of water with 4 ppm fluoride throughout their lives, there appears to be no margin of safety even for crippling fluorosis. In ITS regulations for Drinking Water Contaminants Most Other, EPA has Included safety factors of 10 to 100 and has calculated intakes in terms of a lifetime-that is, 70 years Instead of 20. Joseph A. Cotruvo, director of The criteria and Standards division. of EPA's Office of Drinking Water, says the fact that so few people in the US have actually developed crippling skeletal fluorosis indicates that fluoride levels found in US water are safe and that there is therefore an observed margin of safety. But Critics of EPA's standard speculate that there Probably Have been many more Cases of fluorosis-Even crippling fluorosis-than The few Reported in The literature Because Most doctors in The US Have Not studied The disease and do Not know How to DIAGNOSE it. Those Who. ingest much less than 20 mg of fluoride per day may still be at risk of developing less severe stages of skeletal fluorosis, such as preclinical forms or the subcrippling clinical stages. In its final report, the Surgeon General's panel said that radiologic changes have been found in bone when fluoride exposure has been about 5 mg per day. Nearly all of those drinking water containing 4 ppm of fluoride and about 3% of the more than 124 million people whose water contains only 1 ppm would have intakes as high as this. It is not known, however, what fraction of those with low-level radiologic changes would suffer joint pains or other clinically obvious adverse health effects. In His Landmark Study of Skeletal fluorosis in cryolite Workers in The 1930s, The Danish scientist Kaj Roholm Found that some of those with Stage I of Clinical Skeletal fluorosis suffered Joint pains and stiffness. Although Skeletal fluorosis has been studied intensely in Other Countries for more than. 40 years, virtually no research has been done in the US to determine how many people are afflicted with the earlier stages of the disease, particularly the preclinical stages. Because some of the clinical symptoms mimic arthritis, the first two clinical phases of skeletal fluorosis could be easily misdiagnosed. Skeletal fluorosis is not even discussed in most medical texts under the effects of fluoride; Indeed, a number of texts Say The condition is Almost nonexistent in The US Even IF Aware of The disease is a Doctor, The Early Stages are Difficult to DIAGNOSE. The possibility that fluoride Might Cause Skeletal abnormalities in Children's bones is of particular Concern. In its April 1983 draft report, the Surgeon General's committee wrote that moderate and severe dental fluorosis in children may be accompanied by skeletal changes. Although this statement was omitted from the final report in September 1983, the committee did urge more research into the skeletal effects of fluoride, particularly in children. It wrote: "The effects of various levels of fluoride intake on rapidly developing bone in young children are not well understood. Also, the modifying effects of total intake, length of exposure, other nutritional factors, and debilitating illness are not well understood.". The Committee's Report was written since, PHS and EPA Have no Research undertaken in this Area. PHS has Conducted Several Studies show that it Claims that fluoride levels in US Water Supplies Have Found clearly had no adverse effects on bones. But The Majority of these Studies either Included a Study Population Too Small to Detect Rare effects or excluded People Who would be Most likely to suffer from Skeletal fluorosis, Such As those with Kidney disease. EPA's Approach to subtle, preclinical effects of fluoride on The Skeleton. differs from its usual approach to other environmental agents. For instance, when EPA assessed the health hazards of lead, it made ​​an extraordinary effort to connect the observable effects of low-level exposure (inhibition of certain blood enzymes) with the known adverse effects of slightly higher exposure (decreased synthesis of hemoglobin, anemia. , and possible neurotoxic effects). When it Set ITS standard for Lead in Air, EPA argued that to Prevent more Serious effects, it Needed to Limit The more subtle Biochemical Changes that Lead was provoking in Millions of Children. By contrast, EPA's Assessment of fluoride in Water took an Almost Opposite. tack. By Defining The Most severe Known hazard, crippling Skeletal fluorosis, As The only Effect it was Concerned with Preventing, EPA dismissed all Degrees of fluoride-induced Changes in bones less drastic than crippling fluorosis As Not being Health Concerns. Because fluoride causes denser bones (. osteosclerosis), a number of researchers have compared fluoridated and nonfluoridated areas to see if the incidence and severity of osteoporosis is lower in fluoridated areas. A small number of studies in the past 25 years have reported a lower incidence of hip fractures in areas with fluoridated water, compared with nearby areas with low-fluoride water. For example. a recent report, comparing two towns in Finland, p.

ผลลัพธ์ (อังกฤษ) 3:

Skeletal fluorosis

One solidly established concept in environmental health is that the effects of toxic agents fall on. A continuum of, biological change ranging from undetectable effects at the lowest levels of exposure to severe health damage. At very high doses. As exposure to an, agent increases the first detectable effect may be a subtle, biochemical changeSuch as a decrease in the activity of an enzyme. At somewhat higher doses measurable changes, in some physiological functions. May occur but these, often are not linked to clear symptoms or adverse effects and may, not be harmful. But as, dosage increases. Adverse effects begin to appear-at first mild ones then moderate, ones and finally, severe ones.

.Most environmental health experts believe that the subtlest detectable effects-those with no outward symptoms which are,, Not clearly harmful-should be considered "precursors" of more serious effects. By this logic people who, show such subtle. Changes should be considered at risk for more serious effects if exposure continues.

, Skeletal fluorosisA complicated illness caused by the accumulation of too much fluoride in, the bones has a number of stages. The first two. Stages are, preclinical-that is the patient feels no symptoms but changes have taken place in the body. In the first preclinical. Stage biochemical abnormalities, occur in the blood and in bone composition; in, the secondHistological changes can be observed in the bone in biopsies. Some experts call these changes harmful because they are. Precursors of more serious conditions. Others say they are harmless.

In the early clinical stage of, skeletal fluorosis. Symptoms include pains in the bones and joints; sensations, of burning pricking and tingling, in the limbs; muscle weakness;? Chronic fatigue;And gastrointestinal disorders and reduced appetite. During this phase changes in, the pelvis and spinal column can be. Detected on X-rays. The bone has both a more prominent and more blurred structure.

In the second, clinical stage pains. In the bones become constant and some of the ligaments begin to calcify. Osteoporosis may occur in the, long bonesAnd early symptoms of osteosclerosis (a condition in which the bones become more dense and have abnormal crystalline structure). Are present. Bony spurs may also appear on the limb bones especially around, the knee the elbow, and on, the surface of. Tibia and ulna.

In advanced, skeletal fluorosis called crippling skeletal fluorosis the extremities, become weak and moving. The joints is difficult.The vertebrae partially fuse together crippling the, patient.

Most experts in skeletal fluorosis agree that ingestion. Of 20 mg of fluoride a day for 20 years or more can cause crippling skeletal fluorosis. Doses as low as 2 to 5 mg per day. Can cause the preclinical and earlier clinical stages.

.The situation is complicated because the risk of skeletal fluorosis depends on more than the level of fluoride in the, water. It also depends on nutritional status intake of, vitamin D, and protein absolute amount of calcium and ratio of calcium. To magnesium in, drinking water and other factors.

In parts of India China Africa Japan,,,,, and the Middle FastLarge numbers of people have skeletal fluorosis from drinking naturally fluoridated water. In India about a million people. Have this disease. Most of the victims live in areas where the water fluoride level is 2 ppm, or above but some cases are. Found in communities with natural fluoride levels below 1 ppm.

In the U.S, more than a dozen cases of skeletal fluorosis. Have been reported.Some have occurred at high, fluoride levels others at levels lower than 4 ppm when aggravating conditions, were present. Such as diabetes or impaired kidney function.

In setting the recommended maximum contaminant level for fluoride in drinking. Water in 1986 EPA considered, only crippling skeletal fluorosis as a health effect and established little or no margin of. Safety even for, this disease.(A margin of safety is a difference between the maximum contaminant level and the level at which health effects first occur. In the most susceptible individuals.) According to a Department of Agriculture survey about 3%, of the U.S. Population drinks 4 L. Or more or water per, Therefore day.About 3% of the people who live in areas where the water contains the natural fluoride level of 4 ppm allowed by EPA - such. As certain communities in Texas or South Carolina - are ingesting at least 16 mg of fluoride a day not including, the fluoride. They derive from other sources such as,,, toothpaste food or air.

, AlsoBecause a more or less constant percent of intake is accumulated, in bone persons who consume 8 mg a day for 50 years accumulate. About the same amount of fluoride in their bones as those who consume 20 mg a day for 20 years. Therefore for people, who. Drink 2 L or more per day of water with 4 ppm fluoride throughout, their livesThere appears to be no margin of safety even for crippling fluorosis. In its regulations for most other drinking water. Contaminants EPA has, included safety factors of 10 to 100 and has calculated intakes in terms of a lifetime - that is 70 years,, Instead of 20.

Joseph A. Cotruvo director of, the criteria and standards division of EPA 's Office of, Drinking WaterSays the fact that so few people in the U.S. Have actually developed crippling skeletal fluorosis indicates that fluoride. Levels found in U.S. Water are safe and that there is therefore an observed margin of safety.But critics of EPA 's standard speculate that there probably have been many more cases of fluorosis-even crippling fluorosis-than. The few reported in the literature because most doctors in the U.S. Have not studied the disease and do not know how to. Diagnose it.

Those who ingest much less than 20 mg of fluoride per day may still be at risk of developing less severe stages. Of, skeletal fluorosisSuch as preclinical forms or the subcrippling clinical stages. In its, final report the Surgeon General s panel said that. ' Radiologic changes have been found in bone when fluoride exposure has been about 5 mg per day. Nearly all of those drinking. Water containing 4 ppm of fluoride and about 3% of the more than 124 million people whose water contains only 1 ppm would. Have intakes as high as this.It is, not known however what fraction, of those with low-level radiologic changes would suffer joint pains or other clinically. Obvious adverse health effects. In his landmark study of skeletal fluorosis in cryolite workers in the 1930s the Danish,, Scientist Kaj Roholm found that some of those with stage I of clinical skeletal fluorosis suffered joint pains and stiffness.

.Although skeletal fluorosis has been studied intensely in other countries for more than 40 years virtually no, research. Has been done in the U.S. To determine how many people are afflicted with the earlier stages of, the disease particularly. The preclinical stages. Because some of the clinical symptoms, mimic arthritisThe first two clinical phases of skeletal fluorosis could be easily misdiagnosed. Skeletal fluorosis is not even discussed. In most medical texts under the effects of fluoride; indeed a number, of texts say the condition is almost nonexistent in. The U.S. Even if a doctor is aware of the disease the early, stages are difficult to diagnose.

.The possibility that fluoride might cause skeletal abnormalities in children 's bones is of particular concern. In its April 1983 draft. Report the Surgeon, General 's committee wrote that moderate and severe dental fluorosis in children may be accompanied by. Skeletal changes. Although this statement was omitted from the final report in, September 1983The committee did urge more research into the skeletal effects, of fluoride particularly in children. It wrote: "The effects. Of various levels of fluoride intake on rapidly developing bone in young children are not well understood. Also the modifying,, Effects of total intake length exposure, of, nutritional, other factors and debilitating illness are not well understood."Since the Committee 's report, was written PHS and EPA have undertaken no research in this area.

PHS has conducted several. Studies that it claims show that fluoride levels found in U.S. Water supplies have had no clearly adverse effects on bones.But the majority of these studies either included a study population too small to detect rare effects or excluded people. Who would be most likely to suffer from skeletal fluorosis such as, those with kidney disease.

EPA 's approach, to subtle. Preclinical effects of fluoride on the skeleton differs from its usual approach to other environmental agents, For instance.When EPA assessed the health hazards of lead it made, an extraordinary effort to connect the observable effects of low-level. Exposure (inhibition of certain blood enzymes) with the known adverse effects of slightly higher exposure (decreased synthesis. Of, hemoglobin anemia and possible, neurotoxic effects). When it set its standard for lead, in airEPA argued that to prevent more serious effects it needed, to limit the more subtle biochemical changes that lead was provoking. In millions of children.

By contrast EPA ', s assessment of fluoride in water took an almost opposite tack. By defining the. Most severe known hazard crippling fluorosis as, skeletal, the only effect it was concerned, with preventingEPA dismissed all degrees of fluoride-induced changes in bones less drastic than crippling fluorosis as not being health. Concerns.

Because fluoride causes denser bones (osteosclerosis), a number of researchers have compared fluoridated and. Nonfluoridated areas to see if the incidence and severity of osteoporosis is lower in fluoridated areas.A small number of studies in the past 25 years have reported a lower incidence of hip fractures in areas with fluoridated. Water compared with, nearby areas with low-fluoride water. For example. A, recent report comparing two towns, in Finland P.