In the case of sputum culture and DST before the start of treatment to follow if DST were MDR-TB to be sold as a treatment failure, then registered as MDR-TB and treatment regimen optimized by adjusting the DST at all.
In the case of sputum and send culture DST before treatment begins to follow if the DST found MDR-TB selling is treatment failure then. MDR-TB and treatment formulated with proper dosage. By adjusting the DST.