The effect of continuous irritation causing chronic inflammation in both the windpipe. Beef lungs, blood vessels, lungs, then (the pulmonary vasculature), with significant associated cells is T-lymphocyte (mainly CD8 *), neutrophil and macrophage secretion, several important mediator leukotriene B4, namely interleukin 8 and tumor necrosis factor, etc. There is also an important process that comes associated with pathogenesis is adding another 2 of oxidative stress and imbalance between proteinases with antiproteinases.
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