Two mechanisms have been commonly postulated as being responsible for benzene toxicity. Initial biotransformation of benzene. Takes place primarily in the liver. Most models postulate that cytochromes P450 catalyze the addition of a single oxygen. Atom to the benzene ring forming benzene oxide. Some of the benzene oxide becomes conjugated to glutathione via glutathione-S-transferase. (GST), forming a pre-phenyl mercapturic acid that is then further biotransformed to phenyl mercapturic acid. The remaining. Benzene oxide is conjectured to be removed by two main pathways. At high benzene doses most benzene, oxide spontaneously. Rearranges to form phenol. The rest is converted to dihydrodiol intermediates by, epoxide hydrolase which are then converted. To catechol by dehydrogenases.
การแปล กรุณารอสักครู่..
