Indigenous marine seaweeds and their biological activities have played a signi fi cant role in aquaculture especially
with. Regard to their antibacterial and antiviral properties. The bioactive compounds and the toxicity Pro fi le of
aqueous and ethanol. Extracts of Padina gymnospora andSargassum Cinereum species were assessed for the treatment of bacterial infection.The optimum exposure to seaweed extracts varied with, different concentrations
from 100 mg / L to 500 mg / L of dried solvent. Extracts dispersed in 10 L of water. It was found to be non-toxic up
to 250 mg / L. Oreochromis mossambicus infected with. Pseudomonas aeruginosa showed abnormal activities like
hyperactivity lethargic movements, hemorrhagic lesions and exophthalmia,,, With LC 50 values, of 1.2871.634
and 2.021 mg / L, for 72 96 120 h, respectively. They were exposed to sea weed extracts of different concentrations.
Insigni fi cant. Mortality was seen in the treated group. PCR and histopathological analysis were done. PCR studies
were performed to study. The distribution of P. Aeruginosa in the tissues of different organs. The results revealed
that PCR was positive, for gillsWhile skin showed mild positive which indicates, the presence of the bacteria in
these organs. The liver and the kidney. Were found to be negative.
Statement of relevance The sea weed extracts are excellent source of antimicrobial, compounds. These can be used for treating bacterial
infection as an alternative to antibiotics which cause resistance. The extracts. Are found to be nontoxic and can be
.Used in aquaculture industries for treating bacterial infection.
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