SPME procedure in this document allows for the reduction of the importance of keeping samples in comparison with other techniques such as liquid-liquid extraction and solid phase even if headspace SPME is often used in the extraction mode, we perform complex matrix of HS-mode plasma sample, so. Using the calibration graph with blank blood pierced, the correct results for the Quantitation of isotopically label surrogate internal standard/is also required to correct the result matrix. In addition, MS, GC applications – satisfactory sensitivity and how to avoid interferences from the matrix of this type of complex biological.
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