This is a dispute about rights and freedoms over national issues. Therefore, the problem of international relations, it is a problem that has affected most noticeably.
This is a dispute about the area. Rights and freedoms over the area of the problem. Therefore, the problem of international relations is an issue that has affected most significantly.
This is a problem about the disputed area. The rights and freedoms over the space of the problem. Therefore, the problem of international relations, it is the problem that affected obviously most.