Bitter herbs research project continuously since.1962 and which Lotlika Rao discovered tea ran tin in the gourd. The show effects, reducing blood sugar, blood of experimental animals in 1965 Sucrow proved chemical structure of tea ran tin was found to be a mixture of sitosteryl -. 5 25-stigmastadien-3-beta-ol-D-glucosides ratio and, in 1:1 years 1977 Baldwa and faculty, isolation of similar insulin from the gourd and have effect reducing sugar in 1981 Khana. And of the proof structure of similar to insulin. Found a polypeptide with molecular weight, 11000 dalton and amino acids 166 residues call this substance that polypeptide P bitter substance cue group บิตา ซินซึ่ง is character chemotaxonomic, Kerr Plant of the family Cucurbitaceae cucurbitacin in bitter gourd is Momordicosides momordicins,,And karaviloside K1 charantoside reported that such bitter substance has the effect of reducing sugar
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