Curcumin is an extract derived from a natural anti-cancer effect in multiple species. Curcumin is extracted from plants Curuma longa. The curcumin can induce death in apoptosis via PI3K / Akt signaling pathway in this study found that curcumin can induce death and apoptosis in cancer cells. MCF-7 breast was evaluated by MTT assay, ELISA, DNA fragmentation analysis. curcumin is to stimulate the expression of Bcl-2 family, both pro- and anti-apoptotic. The expression of Bcl-2 family is associated with PI3K / Akt. We found that the expression of Bcl-2 is a limiting factor for the occurrence of apoptosis induced by curcumin in cells MCF-7 and treat with LY294002 is. an inhibitor of PI3K, it will cause increased cell death and apoptosis induced by curcumin also makes Atg7 stopped down, it will increase the potential to induce apoptosis of curcumin, this study reinforces. the hypothesis that inhibition of PI3K / Akt pathway may improve eye on the apoptosis induced by curcumin in cells MCF-7.
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