Skin permeation enhancement technology is a rapidly.Developing field which would significantly increase the.Number of drugs suitable for transdermal, drug deliveryWith the result that skin will become one of major routes of.Drug administration in the next decade. Elucidation of the.Biochemical composition and functioning of the intrinsic.Diffusion barrier of the stratum corneum has prompted.Investigation of chemical and physical means of enhancing.The percutaneous penetration of poorly absorbed drugs.Research in this area has proved the usefulness of chemical.Penetration enhancers in the enhancement of drug perme -.Ation through skin. The role of natural penetration enhancer.Inclusion in topical formulations has been well documented.And will undoubtedly in the, future permit the, delivery of.Broader classes of drugs through the stratum corneum.Further researches should focus on skin irritation with a.View to selecting natural penetration enhancers possessing.Optimum enhancement effects with minimal skin irritation.
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