Resistance to Murine Tumors Conferr

Resistance to Murine Tumors Conferred by Chronic Infection with Intracellular Protozoa, Toxoplasma gondii and Besnoitia jellisoni
John B. Hibbs Jr., Lewis H. Lambert Jr. and Jack S. Remington
+ Author Affiliations

From the Division of Allergy, Immunology, and Infectious Diseases, Palo Alto Medical Research Foundation, and the Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Palo Alto, California
Abstract

Toxoplasma gondii, a common latent intracellular parasite of man, has been shown to confer resistance against intracellular bacteria (e.g., Listeria) and virus (e.g., Mengo) in mice. Since this resistance is mediated by cells and persists for more than one year, it was pertinent to determine if Toxoplasma gondii and a related protozoan, Besnoitia jellisoni confer resistance against transplantable and autochthonus tumors. Significant resistance to development of mammary tumors was noted in C3H/He mice and to leukemia in AKR mice. Similar resistance was noted following challenge with Friend leukemia virus and sarcoma 180 in Swiss-Webster mice.

Footnotes

This research was supported by a grant from the California Division of the American Cancer Society and by grants no. AI 04717 and AI 43421 from the National Institutes of Health.

Please address requests for reprints to Dr. Jack S. Remington, 860 Bryant Street, Palo Alto, California 94301.

ผลลัพธ์ (อังกฤษ) 2:

Tumors resistance to murine CONFERRED by Chronic Infection with Intracellular Protozoa, Toxoplasma gondii and Besnoitia Jellisoni
John B. Hibbs Jr., Lewis H. Lambert Jr. and Jack S. Remington
+ Author Affiliations From the Division of Allergy, Immunology, Infectious Diseases and,. palo Alto Medical Research Foundation, and the Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Palo Alto, California Abstract Toxoplasma gondii, a common latent intracellular parasite of Man, has been shown to Confer resistance against intracellular bacteria (eg. , Listeria) and virus (eg, Mengo) in mice. Since this resistance is mediated by cells and persists for more than one year, it was pertinent to determine if Toxoplasma gondii and a related protozoan, Besnoitia jellisoni confer resistance against transplantable and autochthonus tumors. Significant resistance to development of mammary tumors was noted in C3H / He mice and to leukemia in AKR mice. Challenge with similar resistance was noted following Friend Virus leukemia and sarcoma in Swiss-Webster mice 180. Footnotes This was supported by a Research Grant from the California Division of the American Cancer Society and by Grants no. AI AI 04 717 and 43 421 from the National Institutes of Health. Please address requests for reprints to Dr. Jack S. Remington, 860 Bryant Street, Palo Alto, California 94301.

ผลลัพธ์ (อังกฤษ) 3:

Resistance to Murine Tumors Conferred by Chronic Infection with Intracellular Protozoa Toxoplasma gondii, and Besnoitia. Jellisoni
John B. Hibbs Jr, Lewis H. Lambert Jr. And Jack S. Remington
Author Affiliations

From the Division, of Allergy. Immunology and Infectious, Diseases Palo Alto, Medical Research Foundation and the, Department of Medicine Division of,, Infectious, Diseases