According to a study of a surfactant and cationic niosomes with span20 spermine-cationic lipids are components that result in good gene delivery. This may be due to the cationic lipids that are part of the recipe that makes niosome preparation has a positive charge. Acidic conditions in lysosyme As a result destablize endosomes membrane and release DNA into cells from the carriers. Then, the gene transcription and translation Lysosomotropic detergents such as lipophilic amine, which can be positively charged in acidic condition in the lysosome, which will result in increasing the ability of endosomal escape of the carrier's (Liang and Hughes, 1998. ). So the media that should be studied further is to study the role of cationic niosomes to act to Dr. gene and
mechanism to enter cells, including acts of Boise. Additional intracellular process
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