Randomisation was done by computer in two screening centres and by sequential opening of numbered sealed envelopes in the. Remaining seven centres. During phase one women who, were HPVpositive and aged 35 - 60 years were referred, to colposcopy. Whereas women aged 25 - 34 years were referred to colposcopy only if cytology was also abnormal or HPV testing was persistently. Positive. During phase two women in, the HPV group were referred for colposcopy if the HPV test was positive. Two rounds. Of screening occurred in, each phase and all women had cytology testing only at the second round. The primary endpoint was. The detection of grade 2 and, 3 CIN and of invasive cervical cancers during the fi RST and second screening rounds.
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