The solution state of AmB is known

The solution state of AmB is known to be related to its activity and the aggregates are thought to be the active and least toxic form [16,75,76]. Anderson et al. [29] propose that AmB toxicity is related to the membrane-inserted form leading to cell permeabilization, whereas the anti-fungal effect is based on ergosterol extraction,which interferes with all biochemical pathways depending on the sterol. Our results confirm conclusively that both forms of the drug coexist in membranes formed from natural yeast lipid extracts, but that the extent to which membrane insertion occurs depends intimately on the membrane fatty acid composition, with a low degree of polyunsaturation partly protecting against insertion. The thinning that occurs upon ergosterol
removal in the naturally polyunsaturated P. pastoris membranes is so pronounced that it is likely to interferewith a broad range ofmembrane protein functions through the introduction of a severe hydrophobic

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Die oplossing toestand van AMB is bekend te wees met betrekking tot die aktiwiteite en die gemiddeldes is vermoedelik die aktiewe en die minste giftig vorm [16,75,76] wees. Anderson et al. [29] stel voor dat AMB toksisiteit is wat verband hou met die membraan ingevoeg vorm wat lei tot sel permeabilization, terwyl die anti-swam effek is gebaseer op ergosterol onttrekking, wat inmeng met al biochemiese paaie na gelang van die sterol. Ons resultate bevestig bo alle twyfel dat beide vorme van die dwelm saamleef in membrane gevorm uit natuurlike gis lipied uittreksels, maar dat die mate waarin membraan te voeg plaasvind hang ten nouste op die membraan vetsuursamestelling, met 'n lae graad van polyunsaturation gedeeltelik beskerm teen voeg. Die uitdunning wat plaasvind op ergosterol
in die Wet op Opheffing Natuurlik poli P.