Four new compounds, citrusosides A-

Four new compounds, citrusosides A-D (1-4), and 15 known compounds were isolated from the hexanes and CH2Cl2
extracts of the peels of Citrus hystrix fruits. Compound 1 is a 1-O-isopropyl-6-O-
-D-glucopyranosyl ester of 5′′,9′′-
dimethyl-2′′,8′′-decadienoic acid. Compounds 2-4 possess a 1-O-isopropyl-
-D-glucopyranosyl and a dihydroxyprenylfuranocoumarin
moiety conjugated to the 3-hydroxy-3-methylglutaric acid as diesters. Several furanocoumarins were
evaluated for their cholinesterase inhibitory activity. (R)-(+)-6′-Hydroxy-7′-methoxybergamottin, (R)-(+)-6′,7′-
dihydroxybergamottin, and (+)-isoimparatorin showed IC50 values of 11.2 ( 0.1, 15.4 ( 0.3, and 23 ( 0.2 μM,
respectively. Bioassay results indicated that the presence of a dioxygenated geranyl chain in the test compounds is
crucial for the inhibitory activity.

ผลลัพธ์ (อังกฤษ) 2:

Four New compounds, Citrusosides AD (1-4), and 15 Known compounds were isolated from The HEXANES and CH2Cl2
extracts of peels of Citrus hystrix The Fruits. Compound 1 is a 1-O-isopropyl-6-O -? - D-Glucopyranosyl ester of 5 '', 9 '' -
dimethyl-2 '', 8 '' - Decadienoic acid. Compounds 2-4 possess a 1-O-isopropyl -? - D-Glucopyranosyl and a Dihydroxyprenylfuranocoumarin
moiety conjugated to The 3-hydroxy-3-acid Methylglutaric As Diesters. Several Furanocoumarins were
evaluated for their cholinesterase inhibitory Activity. (R) - (+) - 6'-Hydroxy-7'-Methoxybergamottin, (R) - (+) - 6 ', 7'-
Dihydroxybergamottin, and (+) - Isoimparatorin showed IC50 values ​​of 11.2 (0.1, 15.4 (. 0.3, and 23 (0.2 uM,
respectively. bioassay results indicated that The Presence of a chain in Dioxygenated Geranyl The test compounds is
Crucial for The inhibitory Activity.

ผลลัพธ์ (อังกฤษ) 3:

Four, new compounds citrusosides A-D (1-4), and 15 known compounds were isolated from the Hexanes and CH2Cl2
extracts of. The peels of Citrus hystrix fruits. Compound 1 is a 1-O-isopropyl-6-O -
- D-glucopyranosyl ester of 5 '', 9 '' -
Dimethyl-2 '', '', 8 - decadienoic Acid. Compounds 2-4 possess a 1-O-isopropyl -
- D-glucopyranosyl and a dihydroxyprenylfuranocoumarin
.Moiety conjugated to the 3-hydroxy-3-methylglutaric acid as diesters. Several furanocoumarins were
evaluated for their. Cholinesterase inhibitory activity. (R) - () - 6 '- Hydroxy-7' - methoxybergamottin, (R) - () - 6 ', 7' -
dihydroxybergamottin and (,, ) - isoimparatorin showed IC50 values of 11.2 (0.1 15.4 (,, 0.3 and 23 (0.2, thermal M
respectively.Bioassay results indicated that the presence of a dioxygenated geranyl chain in the test compounds is
crucial for the inhibitory. Activity.
.