The two small and similar viral K+

The two small and similar viral K+ channels Kcv and Kesv are sorted in mammalian cells and yeast to different
destinations. Analysis of the sorting pathways shows that Kcv is trafficking via the secretory pathway
to the plasma membrane, while Kesv is inserted via the TIM/TOM complex to the inner membrane of
mitochondria. Studies with Kesv mutants show that an N-terminal mitochondrial targeting sequence in
this channel is neither necessary nor sufficient for sorting of Kesv the mitochondria. Instead the sorting
of Kesv can be redirected from the mitochondria to the plasma membrane by an insertion of
≥2 amino
acids in a position sensitive manner into the C-terminal transmembrane domain (TMD2) of this channel.
The available data advocate the presence of a C-terminal sorting signal in TMD2 of Kesv channel, which
is presumably not determined by the length of this domain.

ผลลัพธ์ (แอฟริกา) 1:

Die twee klein en K + kanale Virale soortgelyke Kcv en soogdierselle en gis Kesv gesorteer in verskillende
bestemmings. Ontleding van die sortering paaie toon dat handel is Kcv via die sekretoriese Pathway
die plasmamembraan, terwyl Kesv via die TIM / TOM Kompleks aan die binneste membraan van ingevoeg
mitochondria. Studies met 'n N
hierdie is nie nodig nie voldoende is vir Channel Sortering van Kesv die mitochondria. Plaas die sortering
van Kesv Kan herlei word uit die mitochondria om die plasmamembraan deur 'n Invoeging van
≥2 amino
sure in 'n posisie sensitiewe C
Die Advokaat Die teenwoordigheid van 'Data beskikbaar. C
vermoedelik nie, word bepaal deur die lengte van hierdie domein.