1. vaccines that may increase the risk of severe disease through antibody-dependent enhancement (ADE)-Subneutralizing is the anti body antibody cannot remove the virus, but in the opposite direction back to promotion increases the number of viruses in the host cell, which contains the cell receptor Fc on the anti body type is called.2. transport and storage3. costs against benefits when the vaccine already.4. the vaccine does not cover all four serotypes is immunization of serotype 1, there will be anti-body only 1 serotype per. Could prevent infections from serotype 2, 3, 4, and the serotype infections that do not receive the vaccine, it will result in more violence.5. do not understand the true disease mechanism.
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