Calais is a natural substance extracts which have a good biological features in a number of respects. In particular, the main ingredient that is found in the oxyresveratrol helps make skin white. This research aims to develop the formula extracts, in the form of a Calais Nano emulsion. By research from medicine, is in the form of nano-emulsion, which contains oil (Jojoba oil Peppermint oil and Grapeseed oil): surfactants (Span80 and Tween20 Tween80): water without preparation according to the ratio of the ternary phase diagram in diagram, then brought to the ultrasonic measuring particle size, Kate (Sonication) and find potential value.Zeta electric machine Nanoplus then put it to the test substance to release oxyresveratrol Franz diffusion methods using HPLC and cell-based experiments. It found that Peppermint oil ratio: Tw80E: H2O (2:04:04) is the best ratio by particle size are located at 23.0 ± 1.90 nm and Zeta electric potential is-12.51 ± 1.03-volts. Test results for absorption through the skin using Franz diffusion cell found that this medicine can penetrate through the barrier and synthetic membranes have a coefficient of discharge (Flux) is equal to 688.55 μg/cm 2. For testing, release a substance oxyresveratrol by HPLC technique, found that there was a release time oxyresveratrol compound average when analyzing relationships and minute 3.992 linear-linear equations will be y = – x is 7780.4 by 321.08 with correlation coefficient (r2) is equal to 0.9997 considered to be legitimate and have acceptable accuracy. So is this medicine is medicine that is appropriate for the development and application for other products.
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