Ethnopharmacological relevanceDerri

Ethnopharmacological relevance

Derris scandens (Roxb.) Benth. has been used as active ingredient in Thai traditional medicine recipes for pain treatment. Dry stem powder and ethanolic extract also recommended in Thailand National List of Essential Medicines (NLEMs) for musculoskeletal pain treatment as herbal medicine. However, no summarization of clinical effect and safety has been evaluated.

Objective

Our study aimed to determine the clinical effects and safety of D. scandens for musculoskeletal pain treatment compared with standard regimen, nonsteroidal anti-inflammatory drugs (NSAIDs).

Methods

International and Thai databases were searched from inception through August 2015. Comparative randomized controlled trials investigating oral D. scandens for musculoskeletal pain were included. Outcomes of interest included level of pain and adverse event. Mean changes of the outcomes from baseline were compared between D. scandens and NSAIDs by calculating mean difference.

Results

From 42 articles identified, 4 studies involving a total of 414 patients were included for efficacy analysis. The effects of oral D. scandens on reducing pain score were no different from those of non-steroidal anti-inflammatory drugs at any time points (3, 7, 14 days and overall). The overall pain reduction in the D. scandens group was not inferior to treatment with NSAIDs (weighted mean difference 0.06; 95% CI: −0.20, 0.31) without evident of heterogeneity (I2=0.00%, p=0.768). When compared, the adverse events (AEs) of D. scandens showed no different relative risk with NSAIDs. The major adverse events were gastrointestinal symptoms.

ผลลัพธ์ (อังกฤษ) 2:

Ethnopharmacological relevance

Derris scandens (Roxb.) Benth. has been used as active ingredient in Thai traditional medicine recipes for pain treatment. Dry stem powder and ethanolic extract also recommended in Thailand National List of Essential Medicines (NLEMs) for musculoskeletal pain treatment as herbal medicine. However, no summarization of Effect clinical and safety has been evaluated.

Objective

Our Study aimed to Determine the clinical effects and safety of Musculoskeletal Pain Treatment for D. scandens compared with standard regimen, nonsteroidal Anti-inflammatory Drugs (NSAIDs).

Methods

International and Thai. databases were searched from inception through August 2015. Comparative randomized controlled trials investigating oral D. scandens for musculoskeletal pain were included. Outcomes of interest included level of pain and adverse event. Mean Changes from baseline of the outcomes were compared between NSAIDs and D. scandens by calculating Mean difference.

Results

From 42 articles identified, involving a total of 414 patients 4 Studies were included for efficacy Analysis. The effects of oral D. scandens on reducing pain score were no different from those of non-steroidal anti-inflammatory drugs at any time points (3, 7, 14 days and overall). The overall pain reduction in the D. scandens group was not inferior to treatment with NSAIDs (weighted mean difference 0.06; 95% CI: -0.20, 0.31) without evident of heterogeneity (I2 = 0.00%, p = 0.768). When compared, the adverse events (AEs) of D. scandens showed no different relative risk with NSAIDs. The major adverse events were gastrointestinal symptoms.

ผลลัพธ์ (อังกฤษ) 3:

Ethnopharmacological relevance.Derris scandens (Roxb.) Benth. Has been used as active ingredient in Thai traditional medicine recipes for pain, treatment. Dry stem powder and ethanolic extract also recommended in Thailand National List of Essential Medicines (NLEMs) for musculoskeletal. Pain treatment as herbal medicine. However no summarization, of clinical effect and safety has been evaluated.Objective.Our study aimed to determine the clinical effects and safety of D. Scandens for musculoskeletal pain treatment compared. With standard regimen nonsteroidal anti-inflammatory, drugs (NSAIDs).Methods.International and Thai databases were searched from inception through August 2015. Comparative randomized controlled trials. Investigating oral D. Scandens for musculoskeletal pain were included. Outcomes of interest included level of pain and adverse. Event. Mean changes of the outcomes from baseline were compared between D. Scandens and NSAIDs by calculating mean difference.Results.From 42, articles identified 4 studies involving a total of 414 patients were included for efficacy analysis. The effects. Of oral D. Scandens on reducing pain score were no different from those of non-steroidal anti-inflammatory drugs at any. Time points (,, 3 7 14 days and overall). The overall pain reduction in the D. Scandens group was not inferior to treatment. With NSAIDs (weighted mean difference 0.06; 95% CI: signed 0.20 0.31), without evident of heterogeneity (I2 =, = 0.00% P 0.768). When. Compared the adverse, events (AEs) of D. Scandens showed no different relative risk with NSAIDs. The major adverse events. Were gastrointestinal symptoms.