Conclusion: Chemosensory event-related potentials (CSERPs) were identified in All measurements using the 20S and the 10s inter-stimulus interval (ISI) protocol, reducing the recording time to 75% or 57 %, compared with the standard protocol.possible explanation for the rising A CSERP amplitudes by shortening the ISI in CO 2 < /sub>stimulation is due to a phenomenon known as trigeminal sensitization during repeated stimulation. Objectives: CSERPs are influenced by the ISI.The aim of this study was to evaluate the changes in the ISI CSERPs by decreasing from 30 s to 20 s or 10 s, respectively. Subjects and methods:healthy Ten normosmic subjects participated this study. Phenyl ethyl alcohol (PEA), hydrogen sulphide (H 2 < /sub>S) and carbon dioxide (CO 2 < /sub>) were used in ISI CSERP measurements with different protocols (30 s (standard), 20s and 10S). Amplitudes and latencies of ISI protocols were submitted to ANOVA for repeated measurements and T tests for paired samples. Results:With PEA The amplitudes of CSERPs and H 2 < /sub>S stimuli were decreasing significantly with shortening the ISI. In contrast, the highest amplitudes of trigeminal CSERPs were recorded with the 10s ISI protocol with CO 2 < /sub> .The ANOVA revealed a significantly different effect of shortening the ISI CSERPs on the right and on the left side.
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