Mitragynine, concentration 250 micromolar, can induce (inducer) enzyme activity. N-demethylase but inhibits (Inhibitor) the activity of the enzyme Glutathione S-transferase. The results of this study conclude that Mitragynine has the potential to cause drug interactions with Glibenclamide, which is an N-demethylase inducer. Therefore, the use of modern medicine in conjunction with kratom to control blood sugar levels must be under supervision. of the docto
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