Ulipristal acetate [17α-acetoxy-11β

Ulipristal acetate [17α-acetoxy-11β-(4-N,N-dimethyl aminophenyl)-19-norpregna-4,9-diene-3,20-dione]
(UPA), a selective
progesterone receptor modulator (Fig. 1), can prevent unintended
pregnancy by delaying ovulation for up to five days after contraceptive
failure. In August 2010, UPA had gained the FDA’s approval
for use as an oral emergency contraception tablet in the U.S. with
trade name Ella. Until now it is found that Ella may cause serious
side effects including abdominal pain, menstrual disorder, headache,
nausea and so on [1]. In addition, the study for UPA to treat
contraceptive gynecological indications (fibroma uteri, adenomyosis)
and Cushing’s syndrome is in progress [2]. In view of safe
medication and investigating pharmaceutical dynamics of drugs, a
simple, sensitive analytical procedure is needed to determine UPA
in pharmaceutical formulation and in biological fluids. HPLC has
been used to determine UPA in bulk [3]. But to the best of our
knowledge, there were few literatures to analyze UPA in biological
samples.

ผลลัพธ์ (อังกฤษ) 2:

Ulipristal acetate [17α-acetoxy-11β- (4-N, N-dimethyl Aminophenyl) -19-4,9-diene-3,20-Norpregna-dione]
(UPA), a Selective
progesterone receptor modulator (Fig. 1). , Can Prevent Unintended
Pregnancy by delaying ovulation for up to Five days after contraceptive
Failure. In August the 2010th, UPA had gained the FDA's Approval
for use as an oral Emergency contraception Tablet in the US with
Trade NAME Ella. Until now it is that Ella May Cause Found Serious
Side effects including abdominal Pain, menstrual Disorder, headache,
nausea and so on [1]. In addition, for the Study to Treat UPA
contraceptive Gynecological indications (fibroma Uteri, adenomyosis)
and Cushing's Syndrome is in Progress [2]. In View of Safe
Medication and investigating Dynamics of Pharmaceutical Drugs, a
Simple, sensitive analytical procedure is Needed to Determine UPA
formulation in Pharmaceutical and Biological Fluids in. HPLC has
been used in bulk to Determine UPA [3]. But to the best of our
Knowledge, there were few literatures to Analyze UPA in Biological
samples.

ผลลัพธ์ (อังกฤษ) 3:

Ulipristal acetate [17 α - acetoxy-11 β - (4-N N-dimethyl,, Aminophenyl) - 19-norpregna-4 9-diene-3 20-dione,,].(UPA), a selective.Progesterone receptor modulator (Fig. 1), can prevent unintended.Pregnancy by delaying ovulation for up to five days after contraceptive.Failure. In August 2010 UPA had, gained the FDA s approval. "For use as an oral emergency contraception tablet in the U.S. With.Trade name Ella. Until now it is found that Ella may cause serious.Side effects including abdominal pain menstrual disorder headache,,,Nausea and so on []. In, 1 addition the study for UPA to treat.Contraceptive gynecological indications (fibroma, uteri adenomyosis).And Cushing "s syndrome is in progress [2]. In view of safe.Medication and investigating pharmaceutical dynamics, of drugs a.Simple sensitive analytical, procedure is needed to determine UPA.In pharmaceutical formulation and in biological fluids. HPLC has.Been used to determine UPA in bulk [3]. But to the best of our.Knowledge there were, few literatures to analyze UPA in biological.Samples.