A B S T R A C Tγ-Aminobutyric acid

A B S T R A C T
γ-Aminobutyric acid (GABA)-rich yogurt is a novel type of functional fermented-dairy product
in the market. This study investigated the anti-diabetic effects of GABA-rich yogurt fermented
by Streptococcus salivarius subsp. thermophiles fmb5 on streptozotocin-induced diabetic
mice (SIDM). SIDM was administered orally GABA-rich yogurt for six weeks.The results showed
that oral administration of GABA-rich yogurt improved both hyperglycaemia and impaired
glucose tolerance of SIDM with a dose-dependent effect. Notably, GABA-rich yogurt significantly
decreased the concentrations of serum total cholesterol (TC) and triacylglycerol (TG),
whereas remarkably increased the concentrations of high-density lipoprotein cholesterol
(HDL-C) and insulin in serum of SIDM. Furthermore, GABA-rich yogurt normalised hypertrophy
of liver and kidney and restored pancreas islet in SIDM. These results suggest that
GABA-rich yogurt may be effective in improving type 1 diabetes (T1D) and delaying the progression
of diabetes complications. GABA-rich yogurt could be a great functional dairy product
with benefit for T1D patients.

ผลลัพธ์ (แอฟริกา) 1:

OPSOMMING
gamma-amino suur (GABA) is 'n roman ryk Yoghurt tipe funksionele gefermenteerde suiwelprodukte-produk
in die mark. Antidiabetiese effekte hierdie studie het die van GABA-ryk Yoghurt gegiste
deur Streptococcus salivarius subsp. -Streptozotocin veroorsaak diabetes Fmb5 thermophiles op
muise (SIDM). SIDM is mondelings toegedien GABA-ryk Yoghurt ses Weeks.The resultate het getoon
dat orale toediening van GABA-ryk Yoghurt verbeter beide hiperglukemie en verswakte
glukose toleransie met 'n dosis-afhanklike effek van SIDM. Veral, GABA-ryk Yoghurt aansienlik
Toenemend totale serumcholesterol van die konsentrasies (TC) en triasielgliserol (OG),
terwyl die besonder verhoogde digtheid lipoproteïen cholesterol konsentrasies van 'n hoë
(HDL-C) en insulien in serum van SIDM. Verder GABA-ryk Yoghurt genormaliseer hipertrofie
van lewer en niere pankreas en Islet Herstelde in SIDM. Hierdie resultate dui daarop dat
GABA-ryk Yoghurt effektief in Tipe 1 Diabetes Verbetering (T1D) en die vertraging van die vordering Mag wees
van diabetes-komplikasies. GABA-ryk Dairy Yoghurt kan 'n groot funksionele produk
met Voordeel vir T1D pasiënte.