AbstractThe endocannabinoid system

Abstract

The endocannabinoid system modulates many pathophysiological functions, including the brain pathways involved in the regulation of body weight and adipose tissue function. The selective cannabinoid CB1 receptor antagonist, rimonabant, has undergone phase III clinical testing as anti-obesity drug. Obesity is considered a mild inflammatory condition and predisposes individuals to an increased risk of developing many diseases. It has been recently suggested that a successful intervention to treat obesity is a therapy combining weight-reducing drugs with anti-inflammatory ones. In this scenario, rimonabant's anti-obesity action is accompanied by favorable changes in markers for insulin resistance, C-reactive protein, adiponectin, tumor necrosis factor α (TNFα). The results reported by Croci and Zarini in this issue highlight the anti-inflammatory and anti-hyperalgesic effect of rimonabant in obese animals, so suggesting that it could provide a more general and aggressive strategy to protect obese patients from many pathological risks.
Keywords: cannabinoid, diabetes, inflammation, obesity, pain, rimonabant

ผลลัพธ์ (แอฟริกา) 1:

abstrakte
die endocannabinoïde stelsel moduleer baie patofisiologiese funksies, insluitend die brein weë wat betrokke is by die regulering van die liggaam gewig en adipose weefsel funksie. die selektiewe cannabinoid CB1 antagoniste, rimonabant, ondergaan Fase III kliniese toetse as anti-vetsug dwelm.vetsug word beskou as 'n ligte inflammatoriese toestand en vatbaar individue tot 'n verhoogde risiko van die ontwikkeling van baie siektes. dit het onlangs voorgestel dat 'n suksesvolle ingryping vetsug te behandel is 'n kombinasie van terapie om gewig te verminder dwelms met anti-inflammatoriese kinders. in hierdie scenario,rimonabant se anti-vetsug aksie word vergesel deur gunstige veranderings in merkers vir insulienweerstand, C-reaktiewe proteïen, adiponectin, tumor nekrose faktor α (tnfα). die resultate gerapporteer deur Croci en zarini in hierdie kwessie beklemtoon die anti-inflammatoriese en anti-Hiperalgesie effek van rimonabant in vetsugtig diere.so wat daarop dui dat dit 'n meer algemene en aggressiewe strategie vetsugtig pasiënte te beskerm teen baie patologiese risiko's kan voorsien
sleutelwoorde:. cannabinoid, diabetes, inflammasie, vetsug, pyn, rimonabant.