Silk from the silkworm, Bombyx mori

Silk from the silkworm, Bombyx mori,has been used as biomedical suture material for centuries. The unique mechanical
properties of these fibers provided important clinical repair options for many applications. During the past 20 years,some
biocompatibility problems have been reported for silkworm silk; however,contamination from residual sericin (glue-like proteins)
was the likely cause. More recent studies with well-defined silkworm silk fibers and films suggest that the core silk fibroin fibers
exhibit comparable biocompatibility in vitro and in vivo with other commonly used biomaterials such as polylactic acid and
collagen. Furthermore,the unique mechanical properties of the silk fibers,the diversity of side chain chemistries for ‘decoration’
with growth and adhesion factors,and the ability to genetically tailor the protein provide additional rationale for the exploration of
this family of fibrous proteins for biomaterial applications. For example,in designing scaffolds for tissue engineering these
properties are particularly relevant and recent results with bone and ligament formation in vitro support the potential role for this
biomaterial in future applications. To date,studies with silks to address biomaterial and matrix scaffold needs have focused on
silkworm silk. With the diversity of silk-like fibrous proteins from spiders and insects,a range of native or bioengineered variants
can be expected for application to a diverse set of clinical needs.

ผลลัพธ์ (แอฟริกา) 1:

Silk van die sywurm, Bombyx mori, is gebruik as 'n biomediese hegtingsmateriaal vir eeue. Die Unieke meganiese
Properties vesel dien verstande hierdie opsies vir baie belangrike Repair Kliniese toepassings. Gedurende die afgelope 20 jaar, 'n paar
probleme biocompatibiliteit aangemeld vir Sywurm Silk; egter oorblywende besoedeling van sericin (gom-agtige Proteïene)
was waarskynlik die oorsaak. Meer onlangse studies met goed-gedefinieerde Sywurm Silk vesel en Films dui daarop dat die Silk fibroïen kern vesel
Vergelykbare uitstalling biocompatibiliteit in vitro en in vivo Biomateriale saam met ander algemeen soos poly suur en
Kollageen. Verder, die unieke meganiese eienskappe van die Silk vesel, Die diversiteit van Side ketting chemistries vir 'Decoration'
met groei en adhesie faktore, en die vermoë om te geneties Tailor Die proteïen bykomende rasionaal vir die verkenning van
hierdie familie van fibreuse proteïene vir biomateriaal Aansoeke. . Byvoorbeeld, in die ontwerp van hierdie steiers vir Tissue Engineering
Properties is veral relevant en onlangse resultate met beenvorming in vitro en ligament ondersteun Die potensiële rol van hierdie
biomateriaal in Future Aansoeke. Tot op datum, Studies met Silks aan te spreek biomateriaal en Matrix Pythagoras Behoeftes het gefokus op
Sywurm Silk. Die diversiteit van veselagtige met sy-agtige proteïene van spinnekoppe en insekte, 'n Range van inheemse of danksy biotechnologie Variante
verwag kan word vir die aansoek om 'n diverse reeks van Kliniese behoeftes.