Although the mechanism by which cuc

Although the mechanism by which cucurbitacin glycosides act as antioxidants is not well understood, it is generally believed that the beneficial properties of cucurbitacin glycosides are due to their ability to directly interact with reactive oxygen species [20]. The current study shows for the first time that CLG is an effective antioxidant when tested using both ORAC and FRAP assays. These results suggest that CLG could be used to suppress oxygen cellular metabolites. Previous data have demonstrated that the cucurbitacin E glycoside exhibits antioxidant properties, probably through the involvement of a direct scavenging effect on several free radicals [20]. On the other hand, NO can freely interact with oxygen metabolites to yield nitrosating species, and the formation of nitrosamines may be important in the development of colorectal cancer in ulcerative colitis. High levels of nitrosamines have been demonstrated in rectal dialysates of patients with active inflammatory bowel disease [12]. Therefore, the obtained results warrant further research for the clinical application of CLG as chemopreventive agents for advanced ulcerative colitis patients.

ผลลัพธ์ (แอฟริกา) 1:

Hoewel die meganisme waardeur cucurbitacin glikosiede optree as antioksidante is nie goed verstaan ​​nie, dit is algemeen geglo dat die voordelige eienskappe van cucurbitacin glikosiede is as gevolg van hul vermoë om direk met reaktiewe suurstof spesies [20]. Die huidige studie toon vir die eerste keer dat CLG is 'n doeltreffende antioksidant wanneer getoets met behulp van beide ORAC en FRAP toetse. Hierdie resultate dui daarop dat CLG gebruik kan word om suurstof sellulêre metaboliete te onderdruk. Vorige data het getoon dat die cucurbitacin E glikosied uitstallings anti-oksidant eienskappe, waarskynlik deur die betrokkenheid van 'n direkte invloed op die blaas verskeie vrye radikale [20]. Aan die ander kant, kan GEEN vrylik interaksie met suurstof metaboliete te nitrosating spesies oplewer, en die vorming van nitrosamines belang kan wees in die ontwikkeling van kolorektale kanker in ulseratiewe kolitis wees. Hoë vlakke van nitrosamines is gedemonstreer in rektale dialysates van pasiënte met aktiewe IBD [12]. Daarom is die resultate wat verkry is regverdig verdere navorsing vir die kliniese aanwending van CLG as chemopreventive agente vir gevorderde ulseratiewe kolitis pasiënte.