This randomized controlled pilot study was conducted at 19 acute stroke and rehabilitation centers across Japan. Forty-seven. Ischemic stroke patients with at least leg motor weakness admitted within 24 hours of onset were randomly assigned to receive. Continuous intravenous infusions of edaravone 30 mg twice daily for 3 days (short-term group) or 10 - 14 days (long-term group).? The primary endpoints of the study included the degree of leg disuse muscle atrophy as measured, by the percentage change. From baseline in femoral muscle circumference 15 cm above the knee and the, improvement in leg locomotor function as assessed,, By the maximum walking speed over, 10 m 3 months after the onset of stroke.
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