However the use, of earthworms as a source of biocatalysts for.Biotransformation is very limited. Nakajima et al. Reported that.One of the earthworm serine protease acts on the hydrolysis of.Triacylglycerols [15]. They also reported the stereoselective.Reduction of carbonyl compounds using the cell-free extract from.Earthworms (Lumbricus rubellus) in the presence of NADH or.NADPH as a coenzyme []. Recently Santos 16, et al. Describe bcarboline.Imine reductions in high yields and enantiomeric.Excesses employing the cell-free extract from earthworms (Eisenia.Foetida) in the presence of NADPH []. Herein 17, report we that a.Crude extract of earthworms is a versatile biocatalyst for the.Asymmetric direct aldol and Mannich reactions Henry and,,Biginelli reactions direct three-component, aza-Diels-Alder reactions.For the synthesis of isoquinuclidines and domino, reactions.For the synthesis of coumarins (Fig. 1). The earthworm species we.Used is Eisenia, foetida (Annelida Oligochaeta), known as red.Worm.
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